ArticleBMC systems biology2012
In silico identification of a multi-functional regulatory protein involved in Holliday junction resolution in bacteria.
Article in BMC systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
- RNA-binding protein YebC enhances translation of proline-rich amino acid stretches in bacteria.Nature communications · 2025Article
- YebC2 resolves ribosome stalling and increases fitness of cells lacking EF-P and the ABCF ATPase YfmR.PLoS genetics · 2025Article
- YebC2 resolves ribosome stalling at polyprolines independent of EF-P and the ABCF ATPase YfmR.bioRxiv : the preprint server for biology · 2024Article
- Gene Regulation and Transcriptomics.Current issues in molecular biology · 2021Article
- YebC regulates variable surface antigen VlsE expression and is required for host immune evasion in Borrelia burgdorferi.PLoS pathogens · 2020Article
- Understanding Stress Response to High-Arsenic Gold-Bearing Sulfide Concentrate in Extremely Metal-Resistant AcidophileMicroorganisms · 2020Article
- Human serum albumin alters specific genes that can play a role in survival and persistence in Acinetobacter baumannii.Scientific reports · 2018Article
- The Genomic Potentials of NOB and ComammoxFrontiers in microbiology · 2018Article
- YebC, a putative transcriptional factor involved in the regulation of the proteolytic system of Lactobacillus.Scientific reports · 2017Article
- Identification of a Novel Epoxyqueuosine Reductase Family by Comparative Genomics.ACS chemical biology · 2017Article
- Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice.Nature communications · 2016Article
- Reconstruction of Transcription Control Networks in Mollicutes by High-Throughput Identification of Promoters.Frontiers in microbiology · 2016Article
- Escherichia coli genes and pathways involved in surviving extreme exposure to ionizing radiation.Journal of bacteriology · 2014Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHomologous recombination is a fundamental cellular process that is most widely used by cells to rearrange genes and accurately repair DNA double-strand breaks. It may result in the formation of a critical intermediate named Holliday junction, which is a four-way DNA junction and needs to be resolved to allow chromosome segregation. Different Holliday junction resolution systems and enzymes have been characterized from all three domains of life. In bacteria, the RuvABC complex is the most important resolution system.
resultsIn this study, we conducted comparative genomics studies to identify a novel DNA-binding protein, YebC, which may serve as a key transcriptional regulator that mainly regulates the gene expression of RuvABC resolvasome in bacteria. On the other hand, the presence of YebC orthologs in some organisms lacking RuvC implied that it might participate in other biological processes. Further phylogenetic analysis of YebC protein sequences revealed two functionally different subtypes: YebC_I and YebC_II. Distribution of YebC_I is much wider than YebC_II. Only YebC_I proteins may play an important role in regulating RuvABC gene expression in bacteria. Investigation of YebC-like proteins in eukaryotes suggested that they may have originated from YebC_II proteins and evolved a new function as a specific translational activator in mitochondria. Finally, additional phylum-specific genes associated with Holliday junction resolution were predicted.
conclusionsOverall, our data provide new insights into the basic mechanism of Holliday junction resolution and homologous recombination in bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.