ArticleMolecular plant pathology2013
Farther, slower, stronger: how the plant genetic background protects a major resistance gene from breakdown.
Article in Molecular plant pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Role of the Genetic Background in Resistance to Plant Viruses.International journal of molecular sciences · 2018Pooled it
- Tobamoviruses: Advances in Molecular Biology, Host Interactions and Integrated Disease Management.Biology · 2026Review
- Covered smut screening in barley: power analysis and effect on agronomic traits.Plant methods · 2026Article
- The replicative fitness and virulence of potato virus Y evolve differently in pepper lines with different levels of resistance and tolerance.The Journal of general virology · 2026Article
- Adaptation of the Cyst Nematode Globodera pallida to the Colinear Potato Resistant QTLs GpaVMolecular ecology · 2025Article
- The Naturally Occurring Amino Acid Substitution in the VPg α1-α2 Loop Breaks eIF4E-Mediated Resistance to PRSV by Enabling VPg to Re-Hijack Another eIF4E Isoform eIF(iso)4E in Watermelon.Molecular plant pathology · 2024Article
- Globally deployed sorghum aphid resistance gene RMES1 is vulnerable to biotype shifts but is bolstered by RMES2.The plant genome · 2024Article
- AtHVA22a, a plant-specific homologue of Reep/DP1/Yop1 family proteins is involved in turnip mosaic virus propagation.Molecular plant pathology · 2024Article
- Plant eIF4E isoforms as factors of susceptibility and resistance to potyviruses.Frontiers in plant science · 2023Review
- Resequencing worldwide spinach germplasm for identification of field resistance QTLs to downy mildew and assessment of genomic selection methods.Horticulture research · 2022Article
- Unravelling cucumber resistance to several viruses via genome-wide association studies highlighted resistance hotspots and new QTLs.Horticulture research · 2022Article
- Distribution and molecular characterization of potato virus Y (PVY) strains infecting potato (Virusdisease · 2021Article
- Reduced susceptibility to a tobacco bushy top virus Malawi isolate by loss of function in hostBreeding science · 2020Article
- Review
- Genome-wide association mapping of QTLs implied in potato virus Y population sizes in pepper: evidence for widespread resistance QTL pyramiding.Molecular plant pathology · 2020Article
- Virus epidemics, plant-controlled population bottlenecks and the durability of plant resistance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Complete genome characterization and population dynamics of potato virus Y-NTN strain from India.Virusdisease · 2019Article
- Manipulating Cellular Factors to Combat Viruses: A Case Study From the Plant Eukaryotic Translation Initiation Factors eIF4.Frontiers in microbiology · 2019Review
- Impact of genetic drift, selection and accumulation level on virus adaptation to its host plants.Molecular plant pathology · 2018Article
- Assessing the durability and efficiency of landscape-based strategies to deploy plant resistance to pathogens.PLoS computational biology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic resistance provides efficient control of crop diseases, but is limited by pathogen evolution capacities which often result in resistance breakdown. It has been demonstrated recently, in three different pathosystems, that polygenic resistances combining a major-effect gene and quantitative resistance controlled by the genetic background are more durable than monogenic resistances (with the same major gene in a susceptible genetic background), but the underlying mechanisms are unknown. Using the pepper-Potato virus Y system, we examined three mechanisms that could account for the greater durability of the polygenic resistances: (i) the additional quantitative resistance conferred by the genetic background; (ii) the increase in the number of mutations required for resistance breakdown; and (iii) the slower selection of adapted resistance-breaking mutants within the viral population. The three mechanisms were experimentally validated. The first explained a large part of the variation in resistance breakdown frequency and is therefore expected to be a major determinant of resistance durability. Quantitative resistance factors also had an influence on the second mechanism by modifying the virus mutational pathways towards resistance breakdown and could also have an influence on the third mechanism by increasing genetic drift effects on the viral population. The relevance of these results for other plant-pathogen systems and their importance in plant breeding are discussed.
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