ReviewImmunological reviews2012
Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway.
Review in Immunological reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Computational design of synthetic receptors with programmable signalling activity for enhanced cancer T cell therapy.Nature biomedical engineering · 2026Article
- IL-7 promotes naïve T cell motility to enable T cell scanning of dendritic cells in the LN.Cytokine · 2026Article
- Janus Kinase Inhibitors: A New Tool for the Treatment of Axial Spondyloarthritis.International journal of molecular sciences · 2023Review
- IL-7 induces type 2 cytokine response in lung ILC2s and regulates GATA3 and CD25 expression.Journal of leukocyte biology · 2022Article
- A review of JAK-STAT signalling in the pathogenesis of spondyloarthritis and the role of JAK inhibition.Rheumatology (Oxford, England) · 2022Review
- Modeling cell-specific dynamics and regulation of the common gamma chain cytokines.Cell reports · 2021Article
- An Integrated Approach for Determining a Protein-Protein Binding Interface in Solution and an Evaluation of Hydrogen-Deuterium Exchange Kinetics for Adjudicating Candidate Docking Models.Analytical chemistry · 2019Article
- IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates.Nature communications · 2018Article
- Interleukin-7 and Immunosenescence.Journal of immunology research · 2017Review
- IL-7 Induces an Epitope Masking ofMediators of inflammation · 2017Article
- Crystal Structure of a Complex of the Intracellular Domain of Interferon λ Receptor 1 (IFNLR1) and the FERM/SH2 Domains of Human JAK1.Journal of molecular biology · 2016Article
- The common γ-chain cytokine receptor: tricks-and-treats for T cells.Cellular and molecular life sciences : CMLS · 2016Review
- Brief report: serpin Spi2A as a novel modulator of hematopoietic progenitor cell formation.Stem cells (Dayton, Ohio) · 2014Article
- Reversal of tumor immune inhibition using a chimeric cytokine receptor.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Structural basis of the proinflammatory signaling complex mediated by TSLP.Nature structural & molecular biology · 2014Article
- A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease.The Journal of allergy and clinical immunology · 2014Review
- Human cell-based artificial antigen-presenting cells for cancer immunotherapy.Immunological reviews · 2014Review
- Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells.The Journal of biological chemistry · 2013Article
- Insights into immune structure, recognition, and signaling.Immunological reviews · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Over the past 13 years, numerous crystal structures of complexes of the common γ-chain (γ(c)) cytokine receptors and their cytokines have been solved. Even with the remarkable progress in the structural biology of γ(c) receptors and their cytokines or interleukins, there are valuable lessons to be learned from the structural and biophysical studies of interleukin-7 (IL-7) and its α-receptor (IL-7Rα) and comparisons with other γ(c) family members. The structure of the IL-7/IL-7Rα complex teaches that interfaces between the γ(c) interleukins and their receptors can vary in size, polarity, and specificity, and that significant conformational changes might be necessary for complexes of interleukins and their receptors to bind the shared, activating γ(c) receptor. Binding, kinetic, and thermodynamic studies of IL-7 and IL-7Rα show that glycosylation and electrostatics can be important to interactions between interleukins and their receptor, even where the glycans and charged residues are distant from the interface. The structure of the IL-7Rα homodimer is a reminder that often-ignored non-activating complexes likely perform roles just as important to signaling as activating complexes. And last but not least, the structural and biophysical studies help explain and potentially treat the diseases caused by aberrant IL-7 signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.