ReviewImmunological reviews2012
Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function.
Review in Immunological reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery.Nature biotechnology · 2026Article
- Design of solubly expressed miniaturized SMART MHCs.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Targeting cancer with precision: strategical insights into TCR-engineered T cell therapies.Theranostics · 2025Review
- Feature Selection Enhances Peptide Binding Predictions for TCR-Specific Interactions.bioRxiv : the preprint server for biology · 2024Article
- Feature selection enhances peptide binding predictions for TCR-specific interactions.Frontiers in immunology · 2024Article
- TEPCAM: Prediction of T-cell receptor-epitope binding specificity via interpretable deep learning.Protein science : a publication of the Protein Society · 2024Article
- Article
- Immunogenic self-peptides - the great unknowns in autoimmunity: Identifying T-cell epitopes driving the autoimmune response in autoimmune diseases.Frontiers in immunology · 2022Review
- Restricted T-Cell Repertoire in the Epicardial Adipose Tissue of Non-ST Segment Elevation Myocardial Infarction Patients.Frontiers in immunology · 2022Article
- T cell antigen discovery.Nature methods · 2021Review
- Human immune repertoire in hepatitis B virus infection.World journal of gastroenterology · 2021Review
- The discriminatory power of the T cell receptor.eLife · 2021Article
- Prediction of Specific TCR-Peptide Binding From Large Dictionaries of TCR-Peptide Pairs.Frontiers in immunology · 2020Article
- Peptide-MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites.The Journal of biological chemistry · 2018Article
- CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential.Immunological reviews · 2018Review
- Systems Immunology: Learning the Rules of the Immune System.Annual review of immunology · 2018Review
- Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus.Science translational medicine · 2018Article
- Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.Cell · 2018Article
- Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.The Journal of biological chemistry · 2015Article
- Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice.eLife · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Molecular diversity lies at the heart of adaptive immunity. T-cell receptors and peptide-major histocompatibility complex molecules utilize and rely upon an enormous degree of diversity at the levels of genetics, chemistry, and structure to engage one another and carry out their functions. This high level of diversity complicates the systematic study of important aspects of T-cell biology, but recent technical advances have allowed for the ability to study diversity in a comprehensive manner. In this review, we assess insights gained into T-cell receptor function and biology from our increasingly precise ability to assess the T-cell repertoire as a whole or to perturb individual receptors with engineered reagents. We conclude with a perspective on a new class of high-affinity, non-stimulatory peptide ligands we have recently discovered using diversity-oriented techniques that challenges notions for how we think about T-cell receptor signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.