ArticleACS nano2012
Directly observing the motion of DNA molecules near solid-state nanopores.
Article in ACS nano, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Constructing a Nanopipette-Based DNA Electromechanical Device.Nano letters · 2025Article
- Site-Specific Integration of Hexagonal Boron Nitride Quantum Emitters on 2D DNA Origami Nanopores.Nano letters · 2024Article
- Bleach Cleaning of Commercially Available Gold Nanopillar Arrays for Surface-Enhanced Raman Spectroscopy (SERS).Applied spectroscopy · 2024Article
- Article
- Nanopores in Atomically Thin 2D Nanosheets Limit Aqueous Single-Stranded DNA Transport.Physical review letters · 2021Article
- Dynamics of DNA Clogging in Hafnium Oxide Nanopores.The journal of physical chemistry. B · 2020Article
- Sensing with Nanopores and Aptamers: A Way Forward.Sensors (Basel, Switzerland) · 2020Review
- Microfluidic Systems Applied in Solid-State Nanopore Sensors.Micromachines · 2020Review
- Analysis Method of the Ion Current-Time Waveform Obtained from Low Aspect Ratio Solid-state Nanopores.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2020Review
- On-Chip Stretching, Sorting, and Electro-Optical Nanopore Sensing of Ultralong Human Genomic DNA.ACS nano · 2019Article
- Clog and Release, and Reverse Motions of DNA in a Nanopore.Polymers · 2019Article
- Direct observation of DNA knots using a solid-state nanopore.Nature nanotechnology · 2016Article
- Decoding DNA, RNA and peptides with quantum tunnelling.Nature nanotechnology · 2016Review
- Article
- DNA motion induced by electrokinetic flow near an Au coated nanopore surface as voltage controlled gate.Nanotechnology · 2015Article
- Article
- Article
- Threading immobilized DNA molecules through a solid-state nanopore at >100 μs per base rate.ACS nano · 2013Article
- Tracking single-particle dynamics via combined optical and electrical sensing.Scientific reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
We investigate the diffusion and the drift motion of λ DNA molecules near solid-state nanopores prior to their translocation through the nanopores using fluorescence microscopy. The radial dependence of the electric field near a nanopore generated by an applied voltage in ionic solution can be estimated quantitatively in 3D by analyzing the motion of negatively charged DNA molecules. We find that the electric field is approximately spherically symmetric around the nanopore under the conditions investigated. In addition, DNA clogging at the nanopore was directly observed. Surprisingly, the probability of the clogging event increases with increasing external bias voltage. We also find that DNA molecules clogging the nanopore reduce the electric field amplitude at the nanopore membrane surface. To better understand these experimental results, analytical method with Ohm's law and computer simulation with Poisson and Nernst-Planck (PNP) equations are used to calculate the electric field near the nanopore. These results are of great interest in both experimental and theoretical considerations of the motion of DNA molecules near voltage-biased nanopores. These findings will also contribute to the development of solid-state nanopore-based DNA sensing devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.