ArticleProceedings of the National Academy of Sciences of the United States of America2012
Impact of experience-dependent and -independent factors on gene expression in songbird brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sensogenomics of music and Alzheimer's disease: An interdisciplinary view from neuroscience, transcriptomics, and epigenomics.Frontiers in aging neuroscience · 2023Pooled it
- Divergence in expression of a singing-related neuroplasticity gene in the brains of 2 Ficedula flycatchers and their hybrids.G3 (Bethesda, Md.) · 2025Article
- Integrative neural mechanisms for social communication of learned vocal behavior.Frontiers in integrative neuroscience · 2025Review
- Gene co-expression analysis reveals conserved and distinct gene networks between resistant and susceptible Lens ervoides challenged by hemibiotrophic and necrotrophic pathogens.Scientific reports · 2024Article
- Linking the genomic signatures of human beat synchronization and learned song in birds.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Human Genomics and the Biocultural Origin of Music.International journal of molecular sciences · 2021Review
- Dynamic transcriptome landscape in the song nucleus HVC between juvenile and adult zebra finches.Advanced genetics (Hoboken, N.J.) · 2021Article
- DNA Methylation Regulates Transcription Factor-Specific Neurodevelopmental but Not Sexually Dimorphic Gene Expression Dynamics in Zebra Finch Telencephalon.Frontiers in cell and developmental biology · 2021Article
- Acute social isolation alters neurogenomic state in songbird forebrain.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Behavior-related gene regulatory networks: A new level of organization in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- ZEBrA: Zebra finch Expression Brain Atlas-A resource for comparative molecular neuroanatomy and brain evolution studies.The Journal of comparative neurology · 2020Article
- The developmental support hypothesis: adaptive plasticity in neural development in response to cues of social support.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Gene manipulation to test links between genome, brain and behavior in developing songbirds: a test case.The Journal of experimental biology · 2020Review
- Understanding the Loss of Maternal Care in Avian Brood Parasites Using Preoptic Area Transcriptome Comparisons in Brood Parasitic and Non-parasitic Blackbirds.G3 (Bethesda, Md.) · 2019Article
- Curation of microarray oligonucleotides and corresponding ESTs/cDNAs used for gene expression analysis in zebra finches.BMC research notes · 2018Article
- The constitutive differential transcriptome of a brain circuit for vocal learning.BMC genomics · 2018Article
- Advancing behavioural genomics by considering timescale.Nature communications · 2018Review
- Mapping Molecular Datasets Back to the Brain Regions They are Extracted from: Remembering the Native Countries of Hypothalamic Expatriates and Refugees.Advances in neurobiology · 2018Article
- Convergent evidence for the molecular basis of musical traits.Scientific reports · 2016Review
- Resource base influences genome-wide DNA methylation levels in wild baboons (Papio cynocephalus).Molecular ecology · 2016Article
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Authors and funding
18 authors.
Funding
Abstract
Songbirds provide rich natural models for studying the relationships between brain anatomy, behavior, environmental signals, and gene expression. Under the Songbird Neurogenomics Initiative, investigators from 11 laboratories collected brain samples from six species of songbird under a range of experimental conditions, and 488 of these samples were analyzed systematically for gene expression by microarray. ANOVA was used to test 32 planned contrasts in the data, revealing the relative impact of different factors. The brain region from which tissue was taken had the greatest influence on gene expression profile, affecting the majority of signals measured by 18,848 cDNA spots on the microarray. Social and environmental manipulations had a highly variable impact, interpreted here as a manifestation of paradoxical "constitutive plasticity" (fewer inducible genes) during periods of enhanced behavioral responsiveness. Several specific genes were identified that may be important in the evolution of linkages between environmental signals and behavior. The data were also analyzed using weighted gene coexpression network analysis, followed by gene ontology analysis. This revealed modules of coexpressed genes that are also enriched for specific functional annotations, such as "ribosome" (expressed more highly in juvenile brain) and "dopamine metabolic process" (expressed more highly in striatal song control nucleus area X). These results underscore the complexity of influences on neural gene expression and provide a resource for studying how these influences are integrated during natural experience.
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