ArticleProceedings of the National Academy of Sciences of the United States of America2012
A composite bacteriophage alters colonization by an intestinal commensal bacterium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
168 citing papers in PubMed.
- Trial
- Review
- Phage-microbe interactions may contribute to the population structure and dynamics of hydrothermal vent symbionts.ISME communications · 2026Article
- Temperate and filamentous bacteriophages as reservoirs of bacterial virulence in stony coral tissue loss disease.Coral reefs (Online) · 2026Article
- Microbial network assembly in bat flies with differing host specificity from North Africa.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Effects of bacteriophages on gut microbiome functionality.Gut microbes · 2025Review
- Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation.Aging and disease · 2025Review
- Methods of Controlling Microbial Contamination of Food.Pathogens (Basel, Switzerland) · 2025Review
- Insights into ecology, pathogenesis, and biofilm formation ofMicrobiology and molecular biology reviews : MMBR · 2025Review
- Gut phages and their interactions with bacterial and mammalian hosts.Journal of bacteriology · 2025Review
- Lysogen formation governs colonies while lytic infection is more prevalent in single cells of the bloom-forming cyanobacterium,bioRxiv : the preprint server for biology · 2025Article
- Review
- Contrasting viral infection strategies for single cell and colonial Microcystis populations consistent with Black Queen dynamics.The ISME journal · 2025Article
- Harnessing the human gut microbiota: an emerging frontier in combatting multidrug-resistant bacteria.Frontiers in immunology · 2025Review
- Targeted virome deep sequencing reveals frequent herpesvirus detection in intestinal biopsies of inflammatory bowel disease patients.PloS one · 2025Article
- The effects of different lung parts, age, and batches on the lung microbiota of healthy rats.Annals of medicine · 2024Article
- Review
- Viruses contribute to microbial diversification in the rumen ecosystem and are associated with certain animal production traits.Microbiome · 2024Article
- Cell-to-cell heterogeneity drives host-virus coexistence in a bloom-forming alga.The ISME journal · 2024Article
- Interspecies ecological competition rejuvenates decayed Geobacter electroactive biofilm.The ISME journal · 2024Article
108 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
Abstract
The mammalian intestine is home to a dense community of bacteria and its associated bacteriophage (phage). Virtually nothing is known about how phages impact the establishment and maintenance of resident bacterial communities in the intestine. Here, we examine the phages harbored by Enterococcus faecalis, a commensal of the human intestine. We show that E. faecalis strain V583 produces a composite phage (ΦV1/7) derived from two distinct chromosomally encoded prophage elements. One prophage, prophage 1 (ΦV1), encodes the structural genes necessary for phage particle production. Another prophage, prophage 7 (ΦV7), is required for phage infection of susceptible host bacteria. Production of ΦV1/7 is controlled, in part, by nutrient availability, because ΦV1/7 particle numbers are elevated by free amino acids in culture and during growth in the mouse intestine. ΦV1/7 confers an advantage to E. faecalis V583 during competition with other E. faecalis strains in vitro and in vivo. Thus, we propose that E. faecalis V583 uses phage particles to establish and maintain dominance of its intestinal niche in the presence of closely related competing strains. Our findings indicate that bacteriophages can impact the dynamics of bacterial colonization in the mammalian intestinal ecosystem.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.