ArticleProceedings of the National Academy of Sciences of the United States of America2012
Paternal social enrichment effects on maternal behavior and offspring growth.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Pooled it
- The impact of pregestational stress on neurodevelopment: Implications for autism spectrum disorder and attention-deficit/hyperactivity disorder.The Journal of physiology · 2026Review
- Dad's Diet Shapes the Future: How Paternal Nutrition Impacts Placental Development and Childhood Metabolic Health.Molecular nutrition & food research · 2025Review
- Intergenerational influences of paternal combat-related trauma on offspring behavioral and brain function.Neurobiology of stress · 2025Article
- Paternal predatory risk alters parental behavior and offspring phenotypes in biparental Brandt's voles.Current zoology · 2025Article
- Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model.Aging and disease · 2024Article
- Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior.Neurobiology of stress · 2024Article
- The endangered brain: actively preservingRoyal Society open science · 2023Review
- Compensatory enhancement of paternal care in maternally neglected mice family.Animal cells and systems · 2023Article
- On the Role of Seminal Fluid Protein and Nucleic Acid Content in Paternal Epigenetic Inheritance.International journal of molecular sciences · 2022Review
- Article
- Vertical transmission of horizontally acquired social information in sticklebacks: implications for transgenerational plasticity.Proceedings. Biological sciences · 2022Article
- Effects of paternal high-fat diet and maternal rearing environment on the gut microbiota and behavior.Scientific reports · 2022Article
- Single paternal dexamethasone challenge programs offspring metabolism and reveals multiple candidates in RNA-mediated inheritance.iScience · 2021Article
- Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases.International journal of genomics · 2021Review
- Adolescent Substance Abuse, Transgenerational Consequences and Epigenetics.Current neuropharmacology · 2021Article
- Sex-specific plasticity across generations I: Maternal and paternal effects on sons and daughters.The Journal of animal ecology · 2020Article
- Sex-specific plasticity across generations II: Grandpaternal effects are lineage specific and sex specific.The Journal of animal ecology · 2020Article
- Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study.Molecular autism · 2020Article
- Who's your daddy? Behavioral and epigenetic consequences of paternal drug exposure.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Paternal environmental experiences are significant predictors of developmental outcomes in offspring and can occur even in the absence of paternal care. Although there has been a recent focus on the role of environmentally induced changes in the male germline in producing these effects, the potential mediating role of mothers has not been investigated. A role for mothers in the transmission of paternal effects has been well acknowledged in behavioral ecology, which predicts that females will dynamically adjust their reproductive investment in response to the qualities of their mate. In the present study, we show that a lifetime of socially enriched compared with impoverished housing conditions shifts anxiety-like behavior and gene expression of male mice. Females that mate with enriched-reared males exhibit increased levels of pup nursing and licking toward their offspring, which are associated with changes in gene expression within the maternal hypothalamus. Significantly, these changes in maternal behavior are correlated with the general levels of anxiety exhibited by their male mates. Further, we show that paternal environmental enrichment results in increased growth of their offspring. These results suggest that maternal-paternal interactions at mating may guide offspring development, with significant implications for the transgenerational transmission of paternal environmental experiences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.