ArticleProceedings of the National Academy of Sciences of the United States of America2012
Gene-environment interplay in Drosophila melanogaster: chronic food deprivation in early life affects adult exploratory and fitness traits.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- Exploration is associated with socioeconomic disparities in learning and academic achievement in adolescence.Nature communications · 2025Article
- Foraging actively can be advantageous in heterogeneous environments.Biology letters · 2025Article
- Undernutrition-induced stunting-like phenotype inNarra J · 2024Article
- 6Pgdh polymorphism in wild bulb mite populations: prevalence, environmental correlates and life history trade-offs.Experimental & applied acarology · 2024Article
- A multi-faceted role of dual-state dopamine signaling in working memory, attentional control, and intelligence.Frontiers in behavioral neuroscience · 2023Review
- Phenotypic extremes or extreme phenotypes? On the use of large and small-bodied "phenocopied"Current research in insect science · 2023Article
- Review
- Posttraumatic stress disorder: from gene discovery to disease biology.Psychological medicine · 2021Review
- Expression of theJournal of neurogenetics · 2021Article
- Selection on heritable social network positions is context-dependent in Drosophila melanogaster.Nature communications · 2021Article
- DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study.Environmental health perspectives · 2021Article
- Genes and environments, development and time.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Traumatic injury in female Drosophila melanogaster affects the development and induces behavioral abnormalities in the offspring.Behavioral and brain functions : BBF · 2019Article
- Self-regulation and theProceedings of the National Academy of Sciences of the United States of America · 2019Article
- The adult foraging assay (AFA) detects strain and food-deprivation effects in feeding-related traits of Drosophila melanogaster.Journal of insect physiology · 2018Article
- Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers.Acta psychiatrica Scandinavica · 2018Article
- Genetics of dispersal.Biological reviews of the Cambridge Philosophical Society · 2018Review
- A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus.Molecular psychiatry · 2018Article
- The DrosophilaCognitive development · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Early life adversity has known impacts on adult health and behavior, yet little is known about the gene-environment interactions (GEIs) that underlie these consequences. We used the fruit fly Drosophila melanogaster to show that chronic early nutritional adversity interacts with rover and sitter allelic variants of foraging (for) to affect adult exploratory behavior, a phenotype that is critical for foraging, and reproductive fitness. Chronic nutritional adversity during adulthood did not affect rover or sitter adult exploratory behavior; however, early nutritional adversity in the larval period increased sitter but not rover adult exploratory behavior. Increasing for gene expression in the mushroom bodies, an important center of integration in the fly brain, changed the amount of exploratory behavior exhibited by sitter adults when they did not experience early nutritional adversity but had no effect in sitters that experienced early nutritional adversity. Manipulation of the larval nutritional environment also affected adult reproductive output of sitters but not rovers, indicating GEIs on fitness itself. The natural for variants are an excellent model to examine how GEIs underlie the biological embedding of early experience.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.