ArticleProceedings of the National Academy of Sciences of the United States of America2012
Cellular complexity captured in durable silica biocomposites.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- [Tripeptide polymer-based cell-imprinted hydrogels for high-efficiency circulating tumor cell capture].Se pu = Chinese journal of chromatography · 2026Article
- [Advances in application of cell imprinting technology in biomedical field].Se pu = Chinese journal of chromatography · 2026Review
- The Role of Confinement in Biomineralization.Chemical reviews · 2025Review
- 33 Unresolved Questions in Nanoscience and Nanotechnology.ACS nano · 2025Article
- Article
- Deep silicification-assisted long-term preservation of structural and genomic information across biospecies: From micro to macro.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Ultrathin silica-tiling on living cells for chemobiotic catalysis.Nature communications · 2024Article
- Cancer Cell Silicification and Surface Functionalization to Create Microbial Mimetic Cancer Vaccines.Methods in molecular biology (Clifton, N.J.) · 2024Article
- High-Throughput Screening of 3-Dimensional Co-culture Hair Follicle Mimetic Tissue with an Enhanced Extracellular Matrix for the Screening of Hair Growth-Promoting Compounds.Biomaterials research · 2024Article
- Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns.Nature biomedical engineering · 2022Article
- Resilient three-dimensional ordered architectures assembled from nanoparticles by DNA.Science advances · 2021Article
- Shape-Preserved Transformation of Biological Cells into Synthetic Hydrogel Microparticles.Advanced biosystems · 2019Article
- Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Cell-Templated Silica Microparticles with Supported Lipid Bilayers as Artificial Antigen-Presenting Cells for T Cell Activation.Advanced healthcare materials · 2019Article
- Multifunctional nanomedicine with silica: Role of silica in nanoparticles for theranostic, imaging, and drug monitoring.Journal of colloid and interface science · 2018Review
- Bioinspired Silicification Reveals Structural Detail in Self-Assembled Peptide Cages.ACS nano · 2018Article
- Concise Review: Fabrication, Customization, and Application of Cell Mimicking Microparticles in Stem Cell Science.Stem cells translational medicine · 2018Review
- Organosilica Nanoparticles with an Intrinsic Secondary Amine: An Efficient and Reusable Adsorbent for Dyes.ACS applied materials & interfaces · 2017Article
- Artificial cells: from basic science to applications.Materials today (Kidlington, England) · 2016Article
- Silica bioreplication preserves three-dimensional spheroid structures of human pluripotent stem cells and HepG2 cells.Scientific reports · 2015Article
Corrections and comments
- Commented on by
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue-derived cultured cells exhibit a remarkable range of morphological features in vitro, depending on phenotypic expression and environmental interactions. Translation of these cellular architectures into inorganic materials would provide routes to generate hierarchical nanomaterials with stabilized structures and functions. Here, we describe the fabrication of cell/silica composites (CSCs) and their conversion to silica replicas using mammalian cells as scaffolds to direct complex structure formation. Under mildly acidic solution conditions, silica deposition is restricted to the molecularly crowded cellular template. Inter- and intracellular heterogeneity from the nano- to macroscale is captured and dimensionally preserved in CSCs following drying and subjection to extreme temperatures allowing, for instance, size and shape preserving pyrolysis of cellular architectures to form conductive carbon replicas. The structural and behavioral malleability of the starting material (cultured cells) provides opportunities to develop robust and economical biocomposites with programmed structures and functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.