Evidence map›Paper›PMID 23045484›Full record

ArticleJournal of bacteriology2012

Next-generation sequencing and de novo assembly, genome organization, and comparative genomic analyses of the genomes of two Helicobacter pylori isolates from duodenal ulcer patients in India.

Narender Kumar, Asish K Mukhopadhyay, Rajashree Patra, Ronita De, Ramani Baddam, Sabiha Shaik, Jawed Alam, Suma Tiruvayipati, Niyaz Ahmed

Abstract readComparative Study
In one paragraph

Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Phylogenomics of ColombianGut pathogens · 2017
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Helicobacter pylori and gastric cancer: Indian enigma.World journal of gastroenterology · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Narender KumarPathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India.
Asish K Mukhopadhyay
Rajashree Patra
Ronita De
Ramani Baddam
Sabiha Shaik
Jawed Alam
Suma Tiruvayipati
Niyaz Ahmed

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of different H. pylori genotypes in various geographical regions indicates region-specific adaptations during the course of evolution. Complete genomes of H. pylori from countries with high infection burdens, such as India, have not yet been described. Herein we present genome sequences of two H. pylori strains, NAB47 and NAD1, from India. In this report, we briefly mention the sequencing and finishing approaches, genome assembly with downstream statistics, and important features of the two draft genomes, including their phylogenetic status. We believe that these genome sequences and the comparative genomics emanating thereupon will help us to clearly understand the ancestry and biology of the Indian H. pylori genotypes, and this will be helpful in solving the so-called Indian enigma, by which high infection rates do not corroborate the minuscule number of serious outcomes observed, including gastric cancer.

Indexed as

Gene OrderGenome, BacterialHigh-Throughput Nucleotide SequencingCluster AnalysisDNA, BacterialDuodenal UlcerHelicobacter InfectionsHelicobacter pyloriHumansIndiaMolecular Sequence DataPhylogenyUnited StatesDNA, Bacterial

Identifiers

PMID23045484
PMCPMC3486096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.