ArticleThe Journal of physiology2013
Inhibitory mechanisms that generate centre and surround properties in ON and OFF brisk-sustained ganglion cells in the rabbit retina.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- Correlation of contrast sensitivity at low spatial frequencies with myopic shift in Chinese children.BMC ophthalmology · 2025Article
- Lateral lamina V projection neuron axon collaterals connect sensory processing across the dorsal horn of the mouse spinal cord.Scientific reports · 2024Article
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- Signaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells.Neuroscience bulletin · 2022Article
- From Receptive to Perceptive Fields: Size-Dependent Asymmetries in Both Negative Afterimages and Subcortical On and Off Post-Stimulus Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Inhibitory components of retinal bipolar cell receptive fields are differentially modulated by dopamine D1 receptors.Visual neuroscience · 2020Article
- Bayesian hypothesis testing and experimental design for two-photon imaging data.PLoS computational biology · 2019Article
- Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior.Neuron · 2019Article
- Pathway-Specific Asymmetries between ON and OFF Visual Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- General features of inhibition in the inner retina.The Journal of physiology · 2017Review
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- Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells.Scientific reports · 2016Article
- Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling.Journal of neurophysiology · 2016Article
- Temporal properties of dual-peak responses of mouse retinal ganglion cells and effects of inhibitory pathways.Cognitive neurodynamics · 2016Article
- The impact of inhibitory mechanisms in the inner retina on spatial tuning of RGCs.Scientific reports · 2016Article
- The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.PLoS genetics · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lateral inhibition produces the centre-surround organization of retinal receptive fields, in which inhibition driven by the mean luminance enhances the sensitivity of ganglion cells to spatial and temporal contrast. Surround inhibition is generated in both synaptic layers; however, the synaptic mechanisms within the inner plexiform layer are not well characterized within specific classes of retinal ganglion cell. Here, we compared the synaptic circuits generating concentric centre-surround receptive fields in ON and OFF brisk-sustained ganglion cells (BSGCs) in the rabbit retina. We first characterized the synaptic inputs to the centre of ON BSGCs, for comparison with previous results from OFF BSGCs. Similar to wide-field ganglion cells, the spatial extent of the excitatory centre and inhibitory surround was larger for the ON than the OFF BSGCs. The results indicate that the surrounds of ON and OFF BSGCs are generated in both the outer and the inner plexiform layers. The inner plexiform layer surround inhibition comprised GABAergic suppression of excitatory inputs from bipolar cells. However, ON and OFF BSGCs displayed notable differences. Surround suppression of excitatory inputs was weaker in ON than OFF BSGCs, and was mediated largely by GABA(C) receptors in ON BSGCs, and by both GABA(A) and GABA(C) receptors in OFF BSGCs. Large ON pathway-mediated glycinergic inputs to ON and OFF BSGCs also showed surround suppression, while much smaller GABAergic inputs showed weak, if any, spatial tuning. Unlike OFF BSGCs, which receive strong glycinergic crossover inhibition from the ON pathway, the ON BSGCs do not receive crossover inhibition from the OFF pathway. We compare and discuss possible roles for glycinergic inhibition in the two cell types.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.