ReviewNature reviews. Urology2012
Analysing the sperm epigenome: roles in early embryogenesis and assisted reproduction.
Review in Nature reviews. Urology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Association of Lycopene and Male Reproductive Health: Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Different Levels of DNA Methylation Detected in Human Sperms after Morphological Selection Using High Magnification Microscopy.BioMed research international · 2016Trial
- Evaluation ofJournal of the Turkish German Gynecological Association · 2025Article
- Sperm histone modifications may predict success in human assisted reproduction: a pilot study.Journal of assisted reproduction and genetics · 2024Article
- Exploring Differentially Expressed Sperm miRNAs in Idiopathic Recurrent Pregnancy Loss and Their Association with Early Embryonic Development.Non-coding RNA · 2024Article
- Article
- Protamine 2 deficiency results in Septin 12 abnormalities.Frontiers in cell and developmental biology · 2024Article
- Investigating the impact of paternal aging on murine sperm miRNA profiles and their potential link to autism spectrum disorder.Scientific reports · 2023Article
- Differential Sperm Proteomics Reveals the Significance of Fatty Acid Synthase and Clusterin in Idiopathic Recurrent Pregnancy Loss.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Male Contributory Factors in Recurrent Pregnancy Loss.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- R-loop landscape in mature human sperm: Regulatory and evolutionary implications.Frontiers in genetics · 2023Article
- Paternal transgenerational nutritional epigenetic effect: A new insight into nutritional manipulation to reduce the use of antibiotics in animal feeding.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Article
- The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility.PLoS biology · 2022Article
- Predicting male fertility from the sperm methylome: application to 120 bulls with hundreds of artificial insemination records.Clinical epigenetics · 2022Article
- Epigenetics of pregnancy: looking beyond the DNA code.Journal of assisted reproduction and genetics · 2022Review
- An episomal DNA vector platform for the persistent genetic modification of pluripotent stem cells and their differentiated progeny.Stem cell reports · 2022Article
- Perinatal Exposure to Nicotine Alters Sperm RNA Profiles in Rats.Frontiers in endocrinology · 2022Article
- Molecular Profiling of Spermatozoa Reveals Correlations between Morphology and Gene Expression: A Novel Biomarker Panel for Male Infertility.BioMed research international · 2021Article
- Gcn5-Mediated Histone Acetylation Governs Nucleosome Dynamics in Spermiogenesis.Developmental cell · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An understanding of the epigenetic mechanisms involved in sperm production and their impact on the differentiating embryo is essential if we are to optimize fertilization and assisted reproduction techniques in the future. Male germ cells are unique in terms of size, robustness, and chromatin structure, which is highly condensed owing to the replacement of most histones by protamines. Analysis of sperm epigenetics requires specific techniques that enable the isolation of high quality chromatin and associated nucleic acids. Histone modification, DNA methylation and noncoding RNAs have important, but so far underestimated, roles in the production of fertile sperm. Aberrations in these epigenetic processes have detrimental consequences for both early embryo development and assisted reproductive technology. Emerging computational techniques are likely to improve our understanding of chromatin dynamics in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.