ArticleArchives of ophthalmology (Chicago, Ill. : 1960)2012
Evaluation of normal human foveal development using optical coherence tomography and histologic examination.
Article in Archives of ophthalmology (Chicago, Ill. : 1960), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 110 citations in OpenAlex.
- Effect of Prematurity on Foveal Development During Infancy: Increased Foveal Inner and Outer Retina Layer Thicknesses in Extremely Premature Infants.Investigative ophthalmology & visual science · 2026Observational
- Skin Melanin Content and the Foveal Avascular Zone Correlation in a Healthy White Population.Investigative ophthalmology & visual science · 2026Article
- Growth Curve for Infant's "Fixation To Light" Using Gaze Reaction Time.Investigative ophthalmology & visual science · 2025Article
- The Inner Nuclear Layer in Pediatric Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Delayed macular development in preterm infants with spontaneously regressed retinopathy of prematurity.BMC ophthalmology · 2025Observational
- Clinical anatomy of the macula.Medical hypothesis, discovery & innovation ophthalmology journal · 2025Review
- Normative retinal thickness values in children, measured by swept-source optical coherence tomography.Medical hypothesis, discovery & innovation ophthalmology journal · 2025Article
- Article
- The analysis of foveal microvascular anomalies in retinopathy of prematurity after anti-vascular endothelial growth factor therapy using optical coherence tomography angiography.BMC ophthalmology · 2024Article
- Longitudinal Assessment of OCT-Based Measures of Foveal Cone Structure in Achromatopsia.Investigative ophthalmology & visual science · 2024Article
- Macular Curvature in Adults Born Preterm With and Without ROP: Results from the Gutenberg Prematurity Eye Study.Investigative ophthalmology & visual science · 2024Article
- Unusual morphology of foveal Müller glia in an adult human born pre-term.Frontiers in cellular neuroscience · 2024Article
- Foveal Hypoplasia inInternational journal of molecular sciences · 2023Article
- Investigating Determinants and Evaluating Deep Learning Training Approaches for Visual Acuity in Foveal Hypoplasia.Ophthalmology science · 2023Article
- Vitreoretinal biomarkers of retinopathy of prematurity using handheld optical coherence tomography: a review.Frontiers in pediatrics · 2023Review
- Insights into the developing fovea revealed by imaging.Progress in retinal and eye research · 2022Review
- Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity.International journal of ophthalmology · 2022Article
- Macular OCT Characteristics at 36 Weeks' Postmenstrual Age in Infants Examined for Retinopathy of Prematurity.Ophthalmology. Retina · 2021Observational
- Dome-shaped macula in premature infants visualized by handheld spectral-domain optical coherence tomography.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2021Observational
- Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses.Investigative ophthalmology & visual science · 2021Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo assess outer retinal layer maturation during late gestation and early postnatal life using optical coherence tomography and histologic examination.
methodsThirty-nine participants 30 weeks' postmenstrual age or older were imaged using a handheld optical coherence tomography system, for a total of 102 imaging sessions. Foveal images from 16 participants (21 imaging sessions) were normal and evaluated for inner retinal excavation and the presence of outer retinal reflective bands. Reflectivity profiles of central, parafoveal, and parafoveal retina were extracted and were compared with age-matched histologic sections.
resultsThe foveal pit morphologic structure in infants was generally distinguishable from that in adults. Reflectivity profiles showed a single hyperreflective band at the fovea in all the infants younger than 42 weeks' postmenstrual age. Multiple bands were distinguishable in the outer retina at the peri fovea by 32 weeks' postmenstrual age and at the fovea by 3 months' postterm. By 17 months' postnatal, the characteristic appearance of 4 hyperreflective bands was evident across the foveal region. These features are consistent with previous results from histologic examinations. A "temporal divot" was present in some infants, and the foveal pit morphologic structure and the extent of inner retinal excavation were variable.
conclusionsHandheld optical coherence tomography is a viable technique for evaluating neonatal retinas. In premature infants who do not develop retinopathy of prematurity, the foveal region seems to follow a developmental time course similar to that associated with in utero maturation. CLINICAL RELEVANCE: As pediatric optical coherence tomography becomes more common, a better understanding of normal foveal and macular development is needed. Longitudinal imaging offers the opportunity to track postnatal foveal development among preterm infants in whom poor visual outcomes are anticipated or to follow up treatment outcomes in this population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.