ReviewAnatomical record (Hoboken, N.J. : 2007)2012
The use of neurotrophin therapy in the inner ear to augment cochlear implantation outcomes.
Review in Anatomical record (Hoboken, N.J. : 2007), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Local Delivery of Therapeutics to the Inner Ear: The State of the Science.Frontiers in cellular neuroscience · 2019Pooled it
- The auditory nerve implant-concept and device description of a novel electrical auditory prosthesis.Bioelectronic medicine · 2025Review
- Consequences and Mechanisms of Noise-Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Decreasing the physical gap in the neural-electrode interface and related concepts to improve cochlear implant performance.Frontiers in neuroscience · 2024Review
- Nerve Growth Factor and Autoimmune Diseases.Current issues in molecular biology · 2023Review
- Comparison Between the Effect of Intra-Scalar Methylprednisolone and Sodium Hyaluronate in Impedance and Electrically Evoked Compound Action Potentials in Cochlear Implant Patients.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- The effect of the surgical approach and cochlear implant electrode on the structural integrity of the cochlea in human temporal bones.Scientific reports · 2022Article
- The BDNF/TrkB Neurotrophin System in the Sensory Organs of Zebrafish.International journal of molecular sciences · 2022Review
- Estimating health of the implanted cochlea using psychophysical strength-duration functions and electrode configuration.Hearing research · 2022Article
- How electrically evoked compound action potentials in chronically implanted guinea pigs relate to auditory nerve health and electrode impedance.The Journal of the Acoustical Society of America · 2020Article
- Age-Dependency of Neurite Outgrowth in Postnatal Mouse Cochlear Spiral Ganglion Explants.Brain sciences · 2020Article
- Expression and Localization of BDNF/TrkB System in the Zebrafish Inner Ear.International journal of molecular sciences · 2020Article
- Changes over time in the electrically evoked compound action potential (ECAP) interphase gap (IPG) effect following cochlear implantation in Guinea pigs.Hearing research · 2019Article
- Detection of BDNF-Related Proteins in Human Perilymph in Patients With Hearing Loss.Frontiers in neuroscience · 2019Article
- CaBP1 regulates CaMolecular and cellular neurosciences · 2018Article
- Potential of Gene and Cell Therapy for Inner Ear Hair Cells.BioMed research international · 2018Review
- High mobility group box 1 (HMGB1): dual functions in the cochlear auditory neurons in response to stress?Histochemistry and cell biology · 2017Article
- Effects of brain-derived neurotrophic factor (BDNF) on the cochlear nucleus in cats deafened as neonates.Hearing research · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Severe to profound deafness is most often secondary to a loss of or injury to cochlear mechanosensory cells, and there is often an associated loss of the peripheral auditory neural structures, specifically the spiral ganglion neurons and peripheral auditory fibers. Cochlear implantation is currently our best hearing rehabilitation strategy for severe to profound deafness. These implants work by directly electrically stimulating the remnant auditory neural structures within the deafened cochlea. When administered to the deafened cochlea in animal models, neurotrophins, specifically brain derived neurotrophic factor and neurotrophin-3, have been shown to dramatically improve spiral ganglion neuron survival and stimulate peripheral auditory fiber regrowth. In animal models, neurotrophins administered in combination with cochlear implantation has resulted in significant improvements in the electrophysiological and psychophysical measures of outcome. While further research must be done before these therapies can be applied clinically, neurotrophin therapies for the inner ear show great promise in enhancing CI outcomes and the treatment of hearing loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.