ReviewNature reviews. Genetics2012
Genome-wide association studies in mice.
Review in Nature reviews. Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect direction meta-analysis of GWAS identifies extreme, prevalent and shared pleiotropy in a large mammal.Communications biology · 2020Pooled it
- Genome-wide association study for age-related hearing loss (AHL) in the mouse: a meta-analysis.Journal of the Association for Research in Otolaryngology : JARO · 2014Pooled it
- Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice.PLoS genetics · 2014Pooled it
- Validation studies and multiomics analysis of Zhx2 as a candidate quantitative trait gene underlying brain oxycodone metabolite (oxymorphone) levels and behavior.The Journal of pharmacology and experimental therapeutics · 2025Article
- Phenogenomic resources immortalized in a panel of wild-derived strains of five species of house mice.Scientific reports · 2025Article
- Rethinking GWAS: how lessons from genetic screens and artificial intelligence could reveal biological mechanisms.Bioinformatics (Oxford, England) · 2025Article
- Establishing the hybrid rat diversity program: a resource for dissecting complex traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Complementation testing identifies genes mediating effects at quantitative trait loci underlying fear-related behavior.Cell genomics · 2024Article
- Validation of positional candidates Rps6ka6 and Pou3f4 for a locus associated with skeletal muscle mass variability.G3 (Bethesda, Md.) · 2024Article
- Altered Fhod3 expression involved in progressive high-frequency hearing loss via dysregulation of actin polymerization stoichiometry in the cuticular plate.PLoS genetics · 2024Article
- Single-cell methylation analysis of brain tissue prioritizes mutations that alter transcription.Cell genomics · 2023Article
- Combination of GWAS and FMolecular genetics and genomics : MGG · 2023Article
- Neonatal lethality of mouse A/J-7Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
- Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function.eLife · 2022Article
- Genome-wide association studies revealed complex genetic architecture and breeding perspective of maize ear traits.BMC plant biology · 2022Article
- Open problems in human trait genetics.Genome biology · 2022Review
- Genotype calling and haplotype inference from low coverage sequence data in heterozygous plant genome using HetMap.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Hearing loss and tinnitus: association studies for complex-hearing disorders in mouse and man.Human genetics · 2022Review
- Mapping of novel loci involved in lung and colon tumor susceptibility by the use of genetically selected mouse strains.Genes and immunity · 2022Article
- Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility.G3 (Bethesda, Md.) · 2022Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Genome-wide association studies (GWASs) have transformed the field of human genetics and have led to the discovery of hundreds of genes that are implicated in human disease. The technological advances that drove this revolution are now poised to transform genetic studies in model organisms, including mice. However, the design of GWASs in mouse strains is fundamentally different from the design of human GWASs, creating new challenges and opportunities. This Review gives an overview of the novel study designs for mouse GWASs, which dramatically improve both the statistical power and resolution compared to classical gene-mapping approaches.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.