Evidence map›Paper›PMID 23044644›Full record

ReviewAnatomical record (Hoboken, N.J. : 2007)2012

The cochlear implant: historical aspects and future prospects.

Adrien A Eshraghi, Ronen Nazarian, Fred F Telischi, Suhrud M Rajguru, Eric Truy, Chhavi Gupta

2 registry-linked trialsAbstract readHistorical ArticleReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anatomical record (Hoboken, N.J. : 2007), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06729632 narecruitingnot on this mapstarted 2024, after this paper: background citation

Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss

TypeinterventionalSponsorRestorear Devices LLCRan2024 to 2027Enrolled116ConditionsNoise Exposure, Noise-induced Hearing Loss, Noise, Adverse EffectArmsCold pack-delivered mild therapeutic hypothermia
NCT07146841 narecruitingnot on this mapstarted 2020, after this paper: background citation

Evaluating Cochlear Insertion Trauma and Hearing Preservation After Cochlear Implantation (CIPRES): a Study Protocol for a Randomized Single-blind Controlled Trial

TypeinterventionalSponsorUMC UtrechtRan2020 to 2027Enrolled48ConditionsSensorineural Hearing LossArmsRound window insertion, Cochleostomy insertion, Lateral wall array, Periomodiolar electrode array
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Investigation of Vestibular Dysfunction Requires Renewed Research Enthusiasm.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Pooled it
  2. Pooled it
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  17. Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
  18. Article
  19. Review
  20. Anatomical Variations, Surgical Difficulties, and Complications Associated with Cochlear Implantation in Different Age Groups of the Pediatric Population of Nepal: A Tertiary Level Hospital-Based Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adrien A EshraghiDepartment of Otolaryngology, University of Miami Ear Institute, University of Miami Miller School of Medicine, Miami, Florida 33136-1015, USA. aeshraghi@med.miami.edu
Ronen Nazarian
Fred F Telischi
Suhrud M Rajguru
Eric Truy
Chhavi Gupta

Funding

Infrared Photoactivation of Inner-Ear Hair CellsR01DC011481 · NIDCD · MARINE BIOLOGICAL LABORATORY · PI RABBITT, RICHARD D · 2011 to 2013
$984k
NIDCD NIH HHS R01 DC011481
6 · The paper itself

Abstract

The cochlear implant (CI) is the first effective treatment for deafness and severe losses in hearing. As such, the CI is now widely regarded as one of the great advances in modern medicine. This article reviews the key events and discoveries that led up to the current CI systems, and we review and present some among the many possibilities for further improvements in device design and performance. The past achievements include: (1) development of reliable devices that can be used over the lifetime of a patient; (2) development of arrays of implanted electrodes that can stimulate more than one site in the cochlea; and (3) progressive and large improvements in sound processing strategies for CIs. In addition, cooperation between research organizations and companies greatly accelerated the widespread availability and use of safe and effective devices. Possibilities for the future include: (1) use of otoprotective drugs; (2) further improvements in electrode designs and placements; (3) further improvements in sound processing strategies; (4) use of stem cells to replace lost sensory hair cells and neural structures in the cochlea; (5) gene therapy; (6) further reductions in the trauma caused by insertions of electrodes and other manipulations during implant surgeries; and (7) optical rather electrical stimulation of the auditory nerve. Each of these possibilities is the subject of active research. Although great progress has been made to date in the development of the CI, including the first substantial restoration of a human sense, much more progress seems likely and certainly would not be a surprise.

Indexed as

AnimalsCochlear ImplantsDeafnessHistory, 19th CenturyHistory, 20th CenturyHistory, 21st CenturyHumans

Identifiers

PMID23044644
PMCPMC4921065

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.