Evidence map›Paper›PMID 23044545›Full record

ArticleBioinformatics (Oxford, England)2012

fRMA ST: frozen robust multiarray analysis for Affymetrix Exon and Gene ST arrays.

Matthew N McCall, Harris A Jaffee, Rafael A Irizarry

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthew N McCallDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, 265 Crittenden Blvd., CU 420630, Rochester, NY 14642, USA. mccallm@gmail.com
Harris A Jaffee
Rafael A Irizarry

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Preprocessing and Analysis Tools for High-Throughput TechnologiesR01GM083084 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI IRIZARRY, RAFAEL ANGEL · 2007 to 2018
$4.4M
CANCER RESEARCH TRAINING-EXPERIMENTAL THERAPY MODELST32CA009363 · NCI · UNIVERSITY OF ROCHESTER · PI LAND, HARTMUT · 1985 to 2013
$2.9M
Software for the Statistical Analysis of Microarray Probe Level DataR01RR021967 · NCRR · JOHNS HOPKINS UNIVERSITY · PI IRIZARRY, RAFAEL ANGEL · 2007 to 2011
$1.2M
Software for the statistical analysis of microarray probe level dataR01GM103552 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI IRIZARRY, RAFAEL ANGEL · 2012 to 2013
$735k
NCI NIH HHS CA009363NCI NIH HHS T32 CA009363NCRR NIH HHS R01 RR021967NCRR NIH HHS RR021967NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NIGMS NIH HHS GM083084NIGMS NIH HHS GM103552NIGMS NIH HHS R01 GM083084NIGMS NIH HHS R01 GM103552
6 · The paper itself

Abstract

summaryFrozen robust multiarray analysis (fRMA) is a single-array preprocessing algorithm that retains the advantages of multiarray algorithms and removes certain batch effects by downweighting probes that have high between-batch residual variance. Here, we extend the fRMA algorithm to two new microarray platforms--Affymetrix Human Exon and Gene 1.0 ST--by modifying the fRMA probe-level model and extending the frma package to work with oligo ExonFeatureSet and GeneFeatureSet objects. AVAILABILITY AND IMPLEMENTATION: All packages are implemented in R. Source code and binaries are freely available through the Bioconductor project. Convenient links to all software and data packages can be found at http://mnmccall.com/software CONTACT: mccallm@gmail.com.

Indexed as

AlgorithmsSoftwareAlternative SplicingComputational BiologyExonsHumansModels, TheoreticalOligonucleotide Array Sequence AnalysisOligonucleotide ProbesOligonucleotide Probes

Identifiers

PMID23044545
PMCPMC3509489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.