ReviewSleep medicine reviews2013
Coherence and frequency in the reticular activating system (RAS).
Review in Sleep medicine reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Arousal Pathways and Emergence From Sedation
A Multidisciplinary Approach to Manage Gait Difficulty in Parkinson Patients
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
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- Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study.Brain, behavior, & immunity - health · 2025Article
- Deep Brain Stimulation for Parkinson's Disease-A Narrative Review.Biomedicines · 2025Review
- Effects of ketamine and propofol on muscarinic plateau potentials in rat neocortical pyramidal cells.PloS one · 2025Article
- System-level hypothesis of dopamine imbalance in early multiple sclerosis.Frontiers in neurology · 2025Article
- From emotional arousal to executive action. Role of the prefrontal cortex.Brain structure & function · 2024Review
- Orexin Neurons to Sublaterodorsal Tegmental Nucleus Pathway Prevents Sleep Onset REM Sleep-Like Behavior by Relieving the REM Sleep Pressure.Research (Washington, D.C.) · 2024Article
- Cerebellar Purkinje cell firing promotes conscious recovery from anesthesia state through coordinating neuronal communications with motor cortex.Theranostics · 2024Article
- Hyperacute autonomic and cortical function recovery following cardiac arrest resuscitation in a rodent model.Annals of clinical and translational neurology · 2023Article
- Bioelectronic Zeitgebers: targeted neuromodulation to re-establish circadian rhythms.Conference proceedings. IEEE International Conference on Systems, Man, and Cybernetics · 2023Article
- Brainstem volume changes in myalgic encephalomyelitis/chronic fatigue syndrome and long COVID patients.Frontiers in neuroscience · 2023Article
- Pedunculopontine-induced cortical decoupling as the neurophysiological locus of dissociation.Psychological review · 2023Article
- Subcortical and default mode network connectivity is impaired in myalgic encephalomyelitis/chronic fatigue syndrome.Frontiers in neuroscience · 2023Article
- Anti-Correlated Myelin-Sensitive MRI Levels in Humans Consistent with a Subcortical to Sensorimotor Regulatory Process-Multi-Cohort Multi-Modal Evidence.Brain sciences · 2022Article
- The role of gamma oscillations in central nervous system diseases: Mechanism and treatment.Frontiers in cellular neuroscience · 2022Review
- Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates.Scientific reports · 2021Article
- The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer's disease.Acta neuropathologica · 2021Review
- Brainstem Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Scoping Review and Evaluation of Magnetic Resonance Imaging Findings.Frontiers in neurology · 2021Article
- Orexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
This review considers recent evidence showing that cells in the reticular activating system (RAS) exhibit (1) electrical coupling mainly in GABAergic cells, and (2) gamma band activity in virtually all of the cells. Specifically, cells in the mesopontine pedunculopontine nucleus (PPN), intralaminar parafascicular nucleus (Pf), and pontine dorsal subcoeruleus nucleus dorsalis (SubCD) (1) show electrical coupling, and (2) all fire in the beta/gamma band range when maximally activated, but no higher. The mechanism behind electrical coupling is important because the stimulant modafinil was shown to increase electrical coupling. We also provide recent findings demonstrating that all cells in the PPN and Pf have high threshold, voltage-dependent P/Q-type calcium channels that are essential to gamma band activity. On the other hand, all SubCD, and some PPN, cells manifested sodium-dependent subthreshold oscillations. A novel mechanism for sleep-wake control based on transmitter interactions, electrical coupling, and gamma band activity is described. We speculate that continuous sensory input will modulate coupling and induce gamma band activity in the RAS that could participate in the processes of preconscious awareness, and provide the essential stream of information for the formulation of many of our actions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.