ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2012
Variation in airway responsiveness of male C57BL/6 mice from 5 vendors.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- The Inflammatory Response in the Murine Ovalbumin-Induced Skin Inflammation Model Is Robust Despite Major Gut Microbiota Differences.Clinical and translational science · 2026Article
- CXCL11 levels regulate lung Treg responses to deter the onset of HIV-related COPD.Respiratory research · 2026Article
- Sex-specific transcriptomic effects of low-dose inorganic arsenic exposure on bone marrow-derived macrophages.Toxicology · 2025Article
- C3H/HeNSlc mouse with low phospholipid transfer protein expression showed dyslipidemia.Scientific reports · 2023Article
- Long-term effects of prenatal arsenic exposure from gestational day 9 to birth on lung, heart, and immune outcomes in the C57BL/6 mouse model.Toxicology letters · 2023Article
- The microbiome and rodent models of immune mediated diseases.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Review
- Substrains matter in phenotyping of C57BL/6 mice.Experimental animals · 2021Review
- Methylxanthines and Neurodegenerative Diseases: An Update.Nutrients · 2021Review
- The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs.Scientific reports · 2021Article
- Vendor effects on murine gut microbiota and its influence on lipopolysaccharide-induced lung inflammation and Gram-negative pneumonia.Intensive care medicine experimental · 2020Article
- Facility-dependent metabolic phenotype and gut bacterial composition in CD-1 mice from a single vendor: A brief report.PloS one · 2020Article
- Fetal Weight Outcomes in C57BL/6J and C57BL/6NCrl Mice after Oral Colonization withInfection and immunity · 2019Article
- Establishment of different experimental asthma models in mice.Experimental and therapeutic medicine · 2018Article
- Article
- High fat feeding unmasks variable insulin responses in male C57BL/6 mouse substrains.The Journal of endocrinology · 2017Article
- Microbiota composition of simultaneously colonized mice housed under either a gnotobiotic isolator or individually ventilated cage regime.Scientific reports · 2017Article
- Protection and Long-Lived Immunity Induced by the ID93/GLA-SE Vaccine Candidate against a Clinical Mycobacterium tuberculosis Isolate.Clinical and vaccine immunology : CVI · 2016Article
- Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design.FEMS microbiology reviews · 2016Review
- Development of SNP markers for C57BL/6N-derived mouse inbred strains.Experimental animals · 2015Article
- Comparison of Neurological Function in Males and Females from Two Substrains of C57BL/6 Mice.Toxics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Mice are now the most commonly used animal model for the study of asthma. The mouse asthma model has many characteristics of the human pathology, including allergic sensitization and airway hyperresponsiveness. Inbred strains are commonly used to avoid variations due to genetic background, but variations due to rearing environment are not as well recognized. After a change in mouse vendors and a switch from C57BL/6J mice to C57BL/6N mice, we noted significant differences in airway responsiveness between the substrains. To further investigate the effect of vendor, we tested C57BL/6N mice from 3 other vendors and found significant differences between several of the substrains. To test whether this difference was due to genetic drift or rearing environment, we purchased new groups of mice from all 5 vendors, bred them in separate vendor-specific groups under uniform environmental conditions, and tested male first generation (F1) offspring at 8 to 10 wk of age. These F1 mice showed no significant differences in airway responsiveness, indicating that the rearing environment rather than genetic differences was responsible for the initial variation in pulmonary phenotype. The environmental factors that caused the phenotypic variation are unknown. However, differences between vendor in feed components, bedding type, or microbiome could have contributed. Whatever the basis, investigators using mouse models of asthma should be cautious in comparing data from mice obtained from different vendors.
Indexed as
Identifiers
23043804PMC3400687What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.