ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2012
Molecular analysis of Helicobacter pylori virulent-associated genes in hepatobiliary patients.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Pooled it
- Association between Helicobacter pylori and Hepatobiliary Cancer: A Meta-analysis and Systematic Review.Asian Pacific journal of cancer prevention : APJCP · 2024Pooled it
- The immunopathogenesis ofFrontiers in microbiology · 2024Review
- A comparative study of Helicobacter pylori infection in hamsters experimentally infected with liver flukes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis.Scientific reports · 2021Article
- Infection withPathogens (Basel, Switzerland) · 2020Article
- Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma?Parasitology international · 2017Review
- Review
- Coinfection with Helicobacter pylori and Opisthorchis viverrini Enhances the Severity of Hepatobiliary Abnormalities in Hamsters.Infection and immunity · 2017Article
- Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease.Scientific reports · 2017Article
- The carcinogenic liver fluke Opisthorchis viverrini is a reservoir for species of Helicobacter.Asian Pacific journal of cancer prevention : APJCP · 2015Article
- Virulence Factors of Helicobacter pylori: A Review.Clinical medicine insights. Gastroenterology · 2014Review
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe Helicobacter pylori virulence-associated genes in hepatobiliary patients, including vacA, iceA, babA2, cagA and cagE, have not been reported. The aim of this study was to investigate these genes and the association of those and the clinical outcomes in hepatobiliary diseases.
methodsEighty H. pylori-PCR-positive cases were obtained from hepatobiliary patients, representing both cholangiocarcinoma (CCA) (n= 58) and cholelithiasis (n= 22). The diversity of virulence genes was examined by polymerase chain reaction and DNA sequencing. Phylogenetic analysis of cagA was determined using the maximum parsimony method.
resultsThe vacAs1a + c/m1, iceA1 and babA2 genes were the most predominant genotypes in both CCA and cholelithiasis patients. The cagA and cagE genes were found significantly more frequently in patients with CCA than those with cholelithiasis (P < 0.05). The cagA positive samples were the Western-type cagA and showed that almost all of the detected sequences in Thai hepatobiliary and Thai gastric cancer patients were classified in the same cluster but separated from the cluster of Japan and other countries.
conclusionsThe cagA and cagE genes may be associated in the pathogenesis of hepatobiliary diseases, especially of CCA. Besides the bacterial variation, other host factors may be involved in the pathogenesis of hepatobiliary cancer.
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