ArticleBMC infectious diseases2012
Procalcitonin and procalcitonin kinetics for diagnosis and prognosis of intravascular catheter-related bloodstream infections in selected critically ill patients: a prospective observational study.
Article in BMC infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Procalcitonin for predicting catheter-associated bloodstream infection: A meta-analysis.Medicine · 2019Pooled it
- Machine learning risk prediction model for bloodstream infections related to totally implantable venous access ports in patients with cancer.Asia-Pacific journal of oncology nursing · 2024Article
- Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2022Article
- Procalcitonin Increase Is Associated with the Development of Critical Care-Acquired Infections in COVID-19 ARDS.Antibiotics (Basel, Switzerland) · 2021Article
- Analysis of the diagnostic capabilities of urinary neutrophil gelatinase-associated lipocalin and serum procalcitonin for acute kidney injury at the early stage of critical care intensive care unit admission.Journal of clinical laboratory analysis · 2021Article
- Role of procalcitonin use in the management of sepsis.Journal of thoracic disease · 2020Review
- Early diagnostic value of serum procalcitonin levels for catheter-related blood stream infection in first-ever acute ischemic stroke patients.BMC neurology · 2020Article
- Procalcitonin as a prognostic marker for sepsis based on SEPSIS-3.Journal of clinical laboratory analysis · 2019Article
- Biomarkers of Infection: Are They Useful in the ICU?Seminars in respiratory and critical care medicine · 2019Review
- Observational
- Extended-spectrum β-lactamase-producing E. coli septicemia among rectal carriers in the ICU.Medicine · 2018Observational
- Expression of the Long Intergenic Non-Coding RNA (lincRNA) of the NED25 Gene Modulates the microRNA-125b, STAT3, Nitric Oxide, and Procalcitonin Signaling Pathways in Patients with Sepsis.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Roles of Procalcitonin and N-Terminal Pro-B-Type Natriuretic Peptide in Predicting Catheter-Related Bloodstream Infection in Severe Burn Injury Patients.Disease markers · 2018Observational
- Diagnostic and prognostic value of procalcitonin for early intracranial infection after craniotomy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Preliminary study on serum paraoxonase-1 status and chemokine (C-C motif) ligand 2 in hospitalized elderly patients with catheter-associated asymptomatic bacteriuria.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy.Annals of intensive care · 2013Article
- Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients.Critical care (London, England) · 2013Observational
- Procalcitonin levels predict acute kidney injury and prognosis in acute pancreatitis: a prospective study.PloS one · 2013Article
- Article
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10 authors.
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Abstract
backgroundProcalcitonin (PCT) has emerged as a valuable marker of sepsis. The potential role of PCT in diagnosis and therapy monitoring of intravascular catheter-related bloodstream infections (CRBSI) in intensive care unit (ICU) is still unclear and was evaluated.
methodsForty-six patients were included in the study, provided they were free of infection upon admission and presented the first episode of suspected CRBSI during their ICU stay. Patients who had developed any other infection were excluded. PCT was measured daily during the ICU hospitalization. Primary endpoint was proven CRBSI. Therapy monitoring as according to infection control was also evaluated.
resultsAmong the 46 patients, 26 were diagnosed with CRBSI. Median PCT on the day of infection suspicion (D0) was 7.70 and 0.10 ng/ml for patients with and without proven CRBSI, respectively (p < 0.001). The area under the curve (AUC) for PCT was 0.990 (95% CI; 0.972 - 1.000), whereas a cut-off value of 0.70 ng/ml provided sensitivity and specificity of 92.3 and 100% respectively. In contrast, the AUC for white blood cells (WBC) was 0.539 (95% CI; 0.369 - 0.709), and for C-reactive protein (CRP), 0.603 (95% CI; 0.438 - 0.768). PCT was the best predictor of proven infection. Moreover, an increase >0.20 ng/ml of PCT between the D0 and any of the 4 preceding days was associated with a positive predictive value exceeding 96%. PCT concentrations from the D2 to D6 after suspected infection tended to decrease in controlled patients, whereas remained stable in non-controlled subjects. A PCT concentration exceeding 1.5 ng/ml during D3 was associated with lack of responsiveness to therapy (p = 0.028).
conclusionsWe suggest that PCT could be a helpful diagnostic and prognostic marker of CRBSI in critically ill patients. Both absolute values and variations should be considered.
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