ArticleDiabetes care2012
Early childhood infections and the risk of islet autoimmunity: the Diabetes Autoimmunity Study in the Young (DAISY).
Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Coxsackievirus B Infections Are Associated With the Risk of Islet Autoimmunity in Children With Strong Genetic Susceptibility to Type 1 Diabetes-Results From the TRIGR Divia Study.Diabetes/metabolism research and reviews · 2026Article
- Rotavirus Infection as a Contributor to Early-Onset Type 1 Diabetes: Review and Recommendations.Viruses · 2026Review
- Respiratory infections in pregnancy and early life-association with the development of islet autoimmunity and type 1 diabetes in children: systematic review and meta-analysis of observational studies.EClinicalMedicine · 2025Article
- Respiratory infections and type 1 diabetes: Potential roles in pathogenesis.Reviews in medical virology · 2023Review
- No association between incidence of type 1 diabetes and rotavirus vaccination in Swedish children.Frontiers in immunology · 2023Article
- Paediatric rotavirus vaccination, coeliac disease and type 1 diabetes in children: a population-based cohort study.BMC medicine · 2021Article
- Diabetes Mellitus and COVID-19: Associations and Possible Mechanisms.International journal of endocrinology · 2021Review
- Early Onset of Autoimmune Diabetes in Children with Down Syndrome-Two Separate Aetiologies or an Immune System Pre-Programmed for Autoimmunity?Current diabetes reports · 2020Review
- Innate Viral Sensor MDA5 and Coxsackievirus Interplay in Type 1 Diabetes Development.Microorganisms · 2020Review
- Association Between Rotavirus Vaccination and Type 1 Diabetes in Children.JAMA pediatrics · 2020Article
- Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?Therapeutic advances in endocrinology and metabolism · 2020Review
- Enteroviral Infections as a Trigger for Type 1 Diabetes.Current diabetes reports · 2018Review
- Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study.Diabetologia · 2017Article
- Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case-control study.BMC public health · 2016Article
- Type 1 diabetes: A predictable disease.World journal of diabetes · 2015Review
- Daycare attendance, breastfeeding, and the development of type 1 diabetes: the diabetes autoimmunity study in the young.BioMed research international · 2015Article
- Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease.Rheumatic diseases clinics of North America · 2014Review
- Children who develop type 1 diabetes early in life show low levels of carnitine and amino acids at birth: does this finding shed light on the etiopathogenesis of the disease?Nutrition & diabetes · 2013Article
- Article
- The next big idea.Diabetes technology & therapeutics · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveType 1 diabetes is a common chronic childhood disease, and the incidence is increasing globally. Childhood infections are considered a potential environmental trigger of type 1 diabetes. Alternatively, improved hygiene and reduced childhood infections could explain the increase in type 1 diabetes in developed countries. The association of reported illnesses during infancy and later development of islet autoimmunity (IA) were examined in the Diabetes Autoimmunity Study in the Young. RESEARCH DESIGN AND
methodsComplete illness interviews through 9 months of age were collected for 1,729 children-1,174 without a family history of type 1 diabetes and 555 with a first-degree relative with type 1 diabetes. Persistent IA was defined as positive antibodies to insulin, glutamic acid decarboxylase, or tyrosine phosphatase on at least two consecutive study visits.
resultsThere were 109 children with persistent IA among the 1,729 children with illness records. A greater number of gastrointestinal illnesses were associated with an increased risk of IA, but only among children who were exposed to gluten-containing grains (wheat or barley) either <4 months of age (hazard ratio 1.37 [95% CI 1.22-1.55]; P < 0.0001) or ≥7 months of age (1.12 [1.05-1.19]; P = 0.0005) compared with 4-6 months of age (P for interaction = 0.02). There were no associations of upper respiratory symptoms, respiratory illnesses, or fevers with IA.
conclusionsSpecific pathogens such as enteroviruses or rotavirus may increase the risk of IA in the presence of existing inflammation induced by diet.
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