ArticleJournal of bacteriology2012
Conjugal transfer of a virulence plasmid in the opportunistic intracellular actinomycete Rhodococcus equi.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Extracellular Polymeric Substances Produced by Actinomycetes of the GenusInternational journal of molecular sciences · 2026Review
- Multi-host distribution of Rhodococcus equi (Prescottella equi) strains and their phylogenomic clustering.BMC microbiology · 2025Article
- Phenotypical and molecular characterization of Rhodococcus equi isolated from foals in the Agreste region of Pernambuco - Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Exploring the Accessory Genome of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Novel Quantitative PCR forAnimals : an open access journal from MDPI · 2022Article
- Horizontal Spread of Rhodococcus equi Macrolide Resistance Plasmid pRErm46 across EnvironmentalApplied and environmental microbiology · 2020Article
- Article
- The pathogenic actinobacterium Rhodococcus equi: what's in a name?Molecular microbiology · 2019Review
- Effect of Macrolide and Rifampin Resistance on the Fitness of Rhodococcus equi.Applied and environmental microbiology · 2019Article
- VapA of Rhodococcus equi binds phosphatidic acid.Molecular microbiology · 2018Article
- Identification of a VapA virulence factor functional homolog in Rhodococcus equi isolates housing the pVAPB plasmid.PloS one · 2018Article
- Conjugative type IVb pilus recognizes lipopolysaccharide of recipient cells to initiate PAPI-1 pathogenicity island transfer in Pseudomonas aeruginosa.BMC microbiology · 2017Article
- Pangenome and Phylogenomic Analysis of the Pathogenic Actinobacterium Rhodococcus equi.Genome biology and evolution · 2016Article
- Transcriptome reprogramming by plasmid-encoded transcriptional regulators is required for host niche adaption of a macrophage pathogen.Infection and immunity · 2015Article
- Gastritis, Enteritis, and Colitis in Horses.The Veterinary clinics of North America. Equine practice · 2015Review
- An Invertron-Like Linear Plasmid Mediates Intracellular Survival and Virulence in Bovine Isolates of Rhodococcus equi.Infection and immunity · 2015Article
- IcgA is a virulence factor of Rhodococcus equi that modulates intracellular growth.Infection and immunity · 2014Article
- Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Rhodococcus equi is a facultative intracellular, Gram-positive, soilborne actinomycete which can cause severe pyogranulomatous pneumonia with abscessation in young horses (foals) and in immunocompromised people, such as persons with AIDS. All strains of R. equi isolated from foals and approximately a third isolated from humans contain a large, ~81-kb plasmid which is essential for the intramacrophage growth of the organism and for virulence in foals and murine in vivo model systems. We found that the entire virulence plasmid could be transferred from plasmid-containing strains of R. equi (donor) to plasmid-free R. equi strains (recipient) at a high frequency and that plasmid transmission reestablished the capacity for intracellular growth in macrophages. Plasmid transfer required living cells and cell-to-cell contact and was unaffected by the presence of DNase, factors pointing to conjugation as the major means of genetic transfer. Deletion of a putative relaxase-encoding gene, traA, located in the proposed conjugative region of the plasmid, abolished plasmid transfer. Reversion of the traA mutation restored plasmid transmissibility. Finally, plasmid transmission to other Rhodococcus species and some additional related organisms was demonstrated. This is the first study showing a virulence plasmid transfer in R. equi, and it establishes a mechanism by which the virulence plasmid can move among bacteria in the soil.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.