ArticleJournal of bacteriology2012
AhpC is required for optimal production of enterobactin by Escherichia coli.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
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- Iron-based microbial interactions: the role of iron metabolism in the cheese ecosystem.Journal of bacteriology · 2025Review
- Fimsbactin Siderophores From a South African Marine Sponge Symbiont, Marinomonas sp. PE14-40.Microbial biotechnology · 2025Article
- OxyR contributes to the oxidative stress capacity and virulence of hypervirulentFrontiers in cellular and infection microbiology · 2025Article
- Review
- Diverse secondary metabolites are expressed in particle-associated and free-living microorganisms of the permanently anoxic Cariaco Basin.Nature communications · 2023Article
- Less is more: Enterobactin concentration dependency in copper tolerance and toxicity.Frontiers in molecular biosciences · 2022Article
- Nickel exposure reduces enterobactin production in Escherichia coli.MicrobiologyOpen · 2019Article
- Complete Genome Sequence Analysis ofFrontiers in microbiology · 2017Article
- Survival Strategies of the Plant-Associated Bacterium Enterobacter sp. Strain EG16 under Cadmium Stress.Applied and environmental microbiology · 2016Article
- Article
- Escherichia coli Free Radical-Based Killing Mechanism Driven by a Unique Combination of Iron Restriction and Certain Antibiotics.Journal of bacteriology · 2015Article
- Muconic acid production from glucose using enterobactin precursors in Escherichia coli.Journal of industrial microbiology & biotechnology · 2015Article
- Regulation of iron transport systems in Enterobacteriaceae in response to oxygen and iron availability.Journal of inorganic biochemistry · 2014Review
- The alternative role of enterobactin as an oxidative stress protector allows Escherichia coli colony development.PloS one · 2014Article
- Alkyl hydroperoxide reductase repair by Helicobacter pylori methionine sulfoxide reductase.Journal of bacteriology · 2013Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Escherichia coli alkyl hydroperoxide reductase subunit C (AhpC) is a peroxiredoxin that detoxifies peroxides. Here we show an additional role for AhpC in cellular iron metabolism of E. coli. Deletion of ahpC resulted in reduced growth and reduced accumulation of iron by cells grown in low-iron media. Liquid chromatography-mass spectroscopy (LC-MS) analysis of culture supernatants showed that the ahpC mutant secreted much less enterobactin, the siderophore that chelates and transports ferric iron under iron-limiting conditions, than wild-type E. coli did. The ahpC mutant produced less 2,3-dihydroxybenzoate, the intermediate in the enterobactin biosynthesis pathway, and providing 2,3-dihydroxybenzoate restored wild-type growth of the ahpC mutant. These data indicated that the defect was in an early step in enterobactin biosynthesis. Providing additional copies of entC, which functions in the first dedicated step of enterobactin biosynthesis, but not of other enterobactin biosynthesis genes, suppressed the mutant phenotype. Additionally, providing either shikimate or a mixture of para-aminobenzoate, tryptophan, tyrosine, and phenylalanine, which, like enterobactin, are synthesized from the precursor chorismate, also suppressed the mutant phenotype. These data suggested that AhpC affected the activity of EntC or the availability of the chorismate substrate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.