ArticleAJNR. American journal of neuroradiology2013
Multicontrast MR imaging at 7T in multiple sclerosis: highest lesion detection in cortical gray matter with 3D-FLAIR.
Article in AJNR. American journal of neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Imaging cortical multiple sclerosis lesions with ultra-high field MRI.NeuroImage. Clinical · 2021Pooled it
- Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-clinical implementation in the diagnostic process.Nature reviews. Neurology · 2015Guideline
- The value of subtraction MRI in detection of amyloid-related imaging abnormalities with oedema or effusion in Alzheimer's patients: An interobserver study.European radiology · 2018Trial
- Cortical lesions in multiple sclerosis: 25 years of progress, remaining challenges and future directions.Nature reviews. Neurology · 2026Review
- Whole-brain in situ postmortem MR imaging using a combination of sequences for cortical lesion detection in multiple sclerosis.La Radiologia medica · 2026Article
- System-level hypothesis of dopamine imbalance in early multiple sclerosis.Frontiers in neurology · 2025Article
- Review
- Sensitivity of T1/T2-weighted ratio in detection of cortical demyelination is similar to magnetization transfer ratio using post-mortem MRI.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Article
- Chronic inflammation in multiple sclerosis - seeing what was always there.Nature reviews. Neurology · 2019Review
- Beyond T2 and 3T: New MRI techniques for clinicians.Clinical and translational radiation oncology · 2019Review
- Comparison of Multiple Sclerosis Cortical Lesion Types Detected by Multicontrast 3T and 7T MRI.AJNR. American journal of neuroradiology · 2019Article
- Ultrahigh field MR Neuroimaging.Topics in magnetic resonance imaging : TMRI · 2019Article
- MRI of cortical lesions and its use in studying their role in MS pathogenesis and disease course.Brain pathology (Zurich, Switzerland) · 2018Article
- Key clinical benefits of neuroimaging at 7T.NeuroImage · 2018Review
- Cerebellum and neurodegenerative diseases: Beyond conventional magnetic resonance imaging.World journal of radiology · 2017Review
- In-vivo imaging of meningeal inflammation in multiple sclerosis: Presence of evidence or evidence of presence?Multiple sclerosis (Houndmills, Basingstoke, England) · 2017Article
- Resolving the clinico-radiological paradox in multiple sclerosis.F1000Research · 2017Review
- Manual Segmentation of MS Cortical Lesions Using MRI: A Comparison of 3 MRI Reading Protocols.AJNR. American journal of neuroradiology · 2016Article
- Magnetic resonance imaging of the cervical spinal cord in multiple sclerosis at 7T.Multiple sclerosis (Houndmills, Basingstoke, England) · 2016Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purpose7T MR imaging has led to improved detection and classification of cortical MS lesions, mainly based on T2*-weighted gradient-echo sequences. Depiction of cortical GM by using the recommended MS imaging protocol has not yet been investigated at 7T. We aimed to investigate prospectively which recommended sequence for clinical use has the highest value at 7T, in terms of GM and WM lesion detection. MATERIALS AND
methodsThirty-seven patients with MS (mean age, 43.8 years; 25 women) and 7 healthy controls (mean age, 40.4 years; 5 women) underwent multicontrast 7T MR imaging including the recommended clinical 2D-T2WI, 3D-T1WI, 3D-FLAIR, and GM-specific 3D-DIR. Lesions were scored and categorized anatomically by 3 raters, in consensus. The value of sequences was evaluated lesion-wise and patient-wise (Wilcoxon signed-rank test).
resultsAt 7T, 3D-FLAIR detected the highest number of total cortical GM lesions (217), 89% more than 3D-DIR and 87% and 224% more than 2D-T2WI and 3D-T1WI. Patient-wise analysis showed that this difference between 3D-FLAIR and 3D-DIR was statistically significant (P<.04), and most pronounced for the number of mixed lesions (P<.03). 3D-FLAIR also detected the highest number of total WM lesions (2605), but the difference with 3D-DIR and 3D-T1WI was not significant.
conclusionsWhen using recommended clinical sequences at 7T, the best way to detect cortical GM lesions is with 3D-FLAIR and not by GM-specific 3D-DIR or by conventional 2D-T2WI and 3D-T1WI sequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.