ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Endurance exercise training normalizes repolarization and calcium-handling abnormalities, preventing ventricular fibrillation in a model of sudden cardiac death.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Influence of endurance and endurance-strength training on mineral status in women with abdominal obesity: a randomized trial.Medicine · 2019Trial
- Post-exercise heart rate variability recovery after 800-m endurance run load among Cameroonian adolescent's males.Sports medicine and health science · 2023Article
- Article
- Contraction-relaxation coupling is unaltered by exercise training and infarction in isolated canine myocardium.The Journal of general physiology · 2021Article
- Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy.Cardiovascular research · 2020Article
- Exercise Training Stabilizes RyR2-Dependent CaFrontiers in cardiovascular medicine · 2020Article
- Altered Intracellular Calcium Homeostasis and Arrhythmogenesis in the Aged Heart.International journal of molecular sciences · 2019Review
- Exercise training reduces ventricular arrhythmias through restoring calcium handling and sympathetic tone in myocardial infarction mice.Physiological reports · 2019Article
- Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors.Nature reviews. Cardiology · 2018Review
- Heritability of heart rate recovery and vagal rebound after exercise.European journal of applied physiology · 2016Article
- Postnatal Cardiac Autonomic Nervous Control in Pediatric Congenital Heart Disease.Journal of cardiovascular development and disease · 2016Review
- Effect of exercise training and myocardial infarction on force development and contractile kinetics in isolated canine myocardium.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Chronic Omega-3 Polyunsaturated Fatty Acid Treatment Variably Affects Cellular Repolarization in a Healed Post-MI Arrhythmia Model.Frontiers in physiology · 2016Article
- Exercise training-induced bradycardia: evidence for enhanced parasympathetic regulation without changes in intrinsic sinoatrial node function.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Myocardial electrotonic response to submaximal exercise in dogs with healed myocardial infarctions: evidence for β-adrenoceptor mediated enhanced coupling during exercise testing.Frontiers in physiology · 2015Article
- Ibandronate and ventricular arrhythmia risk.Journal of cardiovascular electrophysiology · 2014Article
- Reacting to too much excitement: ROS overproduction elicits arrhythmogenic Ca2+ waves in the heart.The Journal of physiology · 2013Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
The risk of sudden cardiac death is increased following myocardial infarction. Exercise training reduces arrhythmia susceptibility, but the mechanism is unknown. We used a canine model of sudden cardiac death (healed infarction, with ventricular tachyarrhythmias induced by an exercise plus ischemia test, VF+); we previously reported that endurance exercise training was antiarrhythmic in this model (Billman GE. Am J Physiol Heart Circ Physiol 297: H1171-H1193, 2009). A total of 41 VF+ animals were studied, after random assignment to 10 wk of endurance exercise training (EET; n = 21) or a matched sedentary period (n = 20). Following (>1 wk) the final attempted arrhythmia induction, isolated myocytes were used to test the hypotheses that the endurance exercise-induced antiarrhythmic effects resulted from normalization of cellular electrophysiology and/or normalization of calcium handling. EET prevented VF and shortened in vivo repolarization (P < 0.05). EET normalized action potential duration and variability compared with the sedentary group. EET resulted in a further decrement in transient outward current compared with the sedentary VF+ group (P < 0.05). Sedentary VF+ dogs had a significant reduction in repolarizing K(+) current, which was restored by exercise training (P < 0.05). Compared with controls, myocytes from the sedentary VF+ group displayed calcium alternans, increased calcium spark frequency, and increased phosphorylation of S2814 on ryanodine receptor 2. These abnormalities in intracellular calcium handling were attenuated by exercise training (P < 0.05). Exercise training prevented ischemically induced VF, in association with a combination of beneficial effects on cellular electrophysiology and calcium handling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.