ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Heat and α1-adrenergic responsiveness in human skeletal muscle feed arteries: the role of nitric oxide.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Tissue oxygen saturation during hyperthermic progressive central hypovolemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Trial
- Cerebrovascular regulation during heat stress.Experimental physiology · 2026Review
- Central and peripheral haemodynamics at exercise onset: the role of central command.European journal of applied physiology · 2024Article
- Heat therapy improves body composition and muscle function but does not affect capillary or collateral growth in a model of obesity and hindlimb ischemia.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Local Heat Therapy to Accelerate Recovery After Exercise-Induced Muscle Damage.Exercise and sport sciences reviews · 2020Review
- Skeletal muscle adaptations to heat therapy.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Vasodilatory and vascular mitochondrial respiratory function with advancing age: evidence of a free radically mediated link in the human vasculature.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Vasoreactivity of the Murine External Jugular Vein and Carotid Artery.Journal of vascular research · 2020Article
- Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans.American journal of physiology. Heart and circulatory physiology · 2019Article
- CORP: Ultrasound assessment of vascular function with the passive leg movement technique.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- TRPVExperimental physiology · 2017Article
- Exercise training and α1-adrenoreceptor-mediated sympathetic vasoconstriction in resting and contracting skeletal muscle.Physiological reports · 2016Article
- Impact of age on the vasodilatory function of human skeletal muscle feed arteries.American journal of physiology. Heart and circulatory physiology · 2016Article
- Human cardiovascular responses to passive heat stress.Comprehensive Physiology · 2015Review
- α1- and α2-adrenergic responsiveness in human skeletal muscle feed arteries: the role of TRPV ion channels in heat-induced sympatholysis.American journal of physiology. Heart and circulatory physiology · 2014Article
- Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability.Canadian journal of physiology and pharmacology · 2014Article
- Short-term exercise training augments 2-adrenoreceptor-mediated sympathetic vasoconstriction in resting and contracting skeletal muscle.The Journal of physiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Increased local temperature exerts a sympatholytic effect on human skeletal muscle feed arteries. We hypothesized that this attenuated α(1)-adrenergic receptor responsiveness may be due to a temperature-induced increase in nitric oxide (NO) bioavailability, thereby reducing the impact of the α(1)-adrenergic receptor agonist phenylephrine (PE). Thirteen human skeletal muscle feed arteries were harvested, and wire myography was used to generate PE concentration-response curves at 37 °C and 39 °C, with and without the NO synthase (NOS) inhibitor N(G)-monomethyl-L-arginine (L-NMMA). A subset of arteries (n = 4) were exposed to 37 °C or 39 °C, and the protein content of endothelial NOS (eNOS) and α(1)-adrenergic receptors was determined by Western blot analysis. Additionally, cultured bovine endothelial cells were exposed to static or shear stress conditions at 37 °C and 39 °C and assayed for eNOS activation (phosphorylation at Ser(1177)), eNOS expression, and NO metabolites [nitrate + nitrite (NOx)]. Maximal PE-induced vasocontraction (PE(max)) was lower at 39 °C than at 37 °C [39 ± 10 vs. 84 ± 30% maximal response to 100 mM KCl (KCl(max))]. NO blockade restored vasocontraction at 39 °C to that achieved at 37 °C (80 ± 26% KCl(max)). Western blot analysis of the feed arteries revealed that heating increased eNOS protein, but not α(1)-adrenergic receptors. Heating of bovine endothelial cells resulted in greater shear stress-induced eNOS activation and NOx production. Together, these data reveal for the first time that, in human skeletal muscle feed arteries, NO blockade can restore the heat-attenuated α(1)-adrenergic receptor-mediated vasocontraction and implicate endothelium-derived NO bioavailability as a major contributor to heat-induced sympatholysis. Consequently, these findings highlight the important role of vasodilators in modulating the vascular response to vasoconstrictors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.