ArticleArteriosclerosis, thrombosis, and vascular biology2012
Novel mechanism of aortic aneurysm development in mice associated with smoking and leukocytes.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Circulating Protein Mediators Linking Genetically Predicted Smoking to Abdominal Aortic Aneurysm: A Genomic-Proteomic Analysis.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Review
- Recent Advances in Nanomedicine-Mediated Abdominal Aortic Aneurysm Treatment.Small methods · 2025Review
- Identifying Circulating Protein Mediators in the Link Between Smoking and Abdominal Aortic Aneurysm: An Integrated Analysis of Human Proteomic and Genomic Data.medRxiv : the preprint server for health sciences · 2025Article
- Global trends and inequities in smoking-attributable aortic aneurysm burden from 1990 to 2021 with future projections.Frontiers in public health · 2025Article
- Small AAAs: Recommendations for Rodent Model Research for the Identification of Novel Therapeutics.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Status of diagnosis and therapy of abdominal aortic aneurysms.Frontiers in cardiovascular medicine · 2023Review
- Association of gene polymorphisms in FBN1 and TGF-β signaling with the susceptibility and prognostic outcomes of Stanford type B aortic dissection.BMC medical genomics · 2022Article
- The risk of dementia in adults with abdominal aortic aneurysm.Scientific reports · 2022Article
- Nicotine Exacerbates TAAD Formation Induced by Smooth Muscle-Specific Deletion of the TGF-Journal of immunology research · 2021Article
- Smoking and the Pathophysiology of Peripheral Artery Disease.Frontiers in cardiovascular medicine · 2021Review
- Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery.JVS-vascular science · 2021Review
- Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture.International journal of molecular sciences · 2020Review
- Abdominal Aortic Aneurysm: Evolving Controversies and Uncertainties.The International journal of angiology : official publication of the International College of Angiology, Inc · 2018Review
- An association of spleen volume and aortic diameter in patients and in mice with abdominal aortic aneurysm.BMC surgery · 2017Article
- Autoimmunity in the Abdominal Aortic Aneurysm and its Association with Smoking.Aorta (Stamford, Conn.) · 2017Article
- Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture, and Need for Surgical Repair.Circulation · 2017Article
- Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections.Current problems in surgery · 2017Review
- Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Understanding the pathogenesis of abdominal aortic aneurysms.Expert review of cardiovascular therapy · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveThe purpose of this study was to evaluate potential mechanisms promoting abdominal aortic aneurysm development with tobacco smoke (TS) exposure. METHODS AND
resultsExperiments used the elastase perfusion model of abdominal aortic aneurysms with smoke-free controls. The effect of TS exposure was evaluated in C57/Bl6 mice, after broad-spectrum matrix metalloproteinase inhibition with doxycycline and in mice deficient in matrix metalloproteinase-9, matrix metalloproteinase-12, Cathepsin-S, and Neutrophil Elastase. Preparations of washed marrow, spleen, and peripheral blood leukocytes were transferred to smoke-free mice from 6-week TS-exposed mice or smoke-free mice. All mice were euthanized 14 days after elastase perfusion, and the percentage of change in aortic diameter (%Δ aortic diameter) was calculated. Electron microscopy of aortic tissue from animals exposed to TS without elastase exposure did not demonstrate any ultrastructural changes. Neither doxycycline nor any specific elastase deficiency was effective at preventing an increase in %Δ aortic diameter in TS-exposed animals. Smoke exposure for 6 weeks increased the %Δ aortic diameter after a smoke-free interval of up to 6 weeks before elastase perfusion. Leukocyte preparations from TS-exposed mice localized to abdominal aortic aneurysms and increased the %Δ aortic diameter in smoke-free mice.
conclusionsThe effect of TS on the development of abdominal aortic aneurysms is not dependent on the activity of elastolytic enzymes and persists for long periods despite cessation of TS. Alterations in leukocyte response to aortic injury appear to mediate this effect.
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