ArticleGenome biology and evolution2012
Nucleomorph genome sequence of the cryptophyte alga Chroomonas mesostigmatica CCMP1168 reveals lineage-specific gene loss and genome complexity.
Article in Genome biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Nucleomorph phylogenomics suggests a deep and ancient origin of cryptophyte plastids within Rhodophyta.The New phytologist · 2026Article
- Molecular Phylogeny of the SELMA Translocation Machinery Recounts the Evolution of Complex Photosynthetic Eukaryotes.Molecular biology and evolution · 2025Article
- Article
- The chromatin organization of a chlorarachniophyte nucleomorph genome.Genome biology · 2022Article
- What Happened before Losses of Photosynthesis in Cryptophyte Algae?Molecular biology and evolution · 2022Article
- Dinoflagellates with relic endosymbiont nuclei as models for elucidating organellogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Comparative Plastid Genomics of Cryptomonas Species Reveals Fine-Scale Genomic Responses to Loss of Photosynthesis.Genome biology and evolution · 2020Article
- The Known, the New, and a Possible Surprise: A Re-Evaluation of the Nucleomorph-Encoded Proteome of Cryptophytes.Genome biology and evolution · 2019Article
- Nucleomorph Small RNAs in Cryptophyte and Chlorarachniophyte Algae.Genome biology and evolution · 2019Article
- Relative Mutation Rates in Nucleomorph-Bearing Algae.Genome biology and evolution · 2019Article
- Nuclear genome sequence of the plastid-lacking cryptomonad Goniomonas avonlea provides insights into the evolution of secondary plastids.BMC biology · 2018Article
- Iron-Sulfur Cluster Biosynthesis in Algae with Complex Plastids.Genome biology and evolution · 2018Article
- Evolution and Diversity of Pre-mRNA Splicing in Highly Reduced Nucleomorph Genomes.Genome biology and evolution · 2018Article
- The cryptomonad nucleomorph.Protoplasma · 2017Article
- Review: origin of complex algae by secondary endosymbiosis: a journey through time.Protoplasma · 2017Review
- Evolutionary Dynamics of Cryptophyte Plastid Genomes.Genome biology and evolution · 2017Article
- Regulation of chloroplast and nucleomorph replication by the cell cycle in the cryptophyte Guillardia theta.Scientific reports · 2017Article
- Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell.BMC evolutionary biology · 2016Article
- Nothing in Evolution Makes Sense Except in the Light of Genomics: Read-Write Genome Evolution as an Active Biological Process.Biology · 2016Review
- Conservation and divergence of the histone code in nucleomorphs.Biology direct · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Cryptophytes are a diverse lineage of marine and freshwater, photosynthetic and secondarily nonphotosynthetic algae that acquired their plastids (chloroplasts) by "secondary" (i.e., eukaryote-eukaryote) endosymbiosis. Consequently, they are among the most genetically complex cells known and have four genomes: a mitochondrial, plastid, "master" nuclear, and residual nuclear genome of secondary endosymbiotic origin, the so-called "nucleomorph" genome. Sequenced nucleomorph genomes are ∼1,000-kilobase pairs (Kbp) or less in size and are comprised of three linear, compositionally biased chromosomes. Although most functionally annotated nucleomorph genes encode proteins involved in core eukaryotic processes, up to 40% of the genes in these genomes remain unidentifiable. To gain insight into the function and evolutionary fate of nucleomorph genomes, we used 454 and Illumina technologies to completely sequence the nucleomorph genome of the cryptophyte Chroomonas mesostigmatica CCMP1168. At 702.9 Kbp in size, the C. mesostigmatica nucleomorph genome is the largest and the most complex nucleomorph genome sequenced to date. Our comparative analyses reveal the existence of a highly conserved core set of genes required for maintenance of the cryptophyte nucleomorph and plastid, as well as examples of lineage-specific gene loss resulting in differential loss of typical eukaryotic functions, e.g., proteasome-mediated protein degradation, in the four cryptophyte lineages examined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.