Evidence map›Paper›PMID 23042485›Full record

ArticleMuscle & nerve2013

Surgical and postpartum hereditary brachial plexus attacks and prophylactic immunotherapy.

Christopher J Klein, David W Barbara, Juraj Sprung, Peter J Dyck, Toby N Weingarten

Open access · greenAbstract read
In one paragraph

Article in Muscle & nerve, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christopher J KleinDepartment of Neurology, Division of Peripheral Nerve Diseases and Medical Genetics, Mayo Clinic Foundation, 200 First Street S.W., Rochester, Minnesota, USA. klein.christopher@mayo.edu
David W Barbara
Juraj Sprung
Peter J Dyck
Toby N Weingarten
Mayo Clinic · US

Funding

DIABETIC NEUROPATHY STUDYR01NS036797 · NINDS · MAYO CLINIC ROCHESTER · PI DYCK, PETER JAMES · 1997 to 2008
$6.8M
Identification of Genetic Causes of Hereditary Sensory and Autonomic NeuropathiesK08NS065007 · NINDS · MAYO CLINIC ROCHESTER · PI KLEIN, CHRISTOPHER · 2009 to 2013
$855k
NINDS NIH HHS K08 NS065007NINDS NIH HHS K08 NS065007-01A1NINDS NIH HHS NS36797NINDS NIH HHS R01 NS036797
6 · The paper itself

Abstract

introductionSurgery and childbirth can trigger attacks of hereditary brachial plexus neuropathy (HBPN), and inflammation was suggested as a component of the pathogenesis.

methodsHBPN patients who underwent surgery or parturition from January 1, 1996 to December 31, 2009 were studied.

resultsTwenty-five HBPN patients underwent 48 surgeries or parturitions. Seventeen patients (68%) had attacks, including 13 periprocedural and 7 postpartum by varied anesthesia types. Three patients who had 8 earlier combined attacks (after thyroidectomy, laminectomy, and Caesarean section) were given prophylactic immunosuppressive therapy (corticosteroids ± immunoglobulin). None suffered postoperative attacks, which is uncharacteristic of their prior experience. Five had perioperative attacks as their first HBPN manifestation. Median follow-up was 11 months (3-48 months). Attacks occurred in the operated limb (n = 6) or distant (n = 7) to surgical sites. All attacks interfered with daily living, with frequent incomplete recovery. Five patients had a SEPT9 mutation.

conclusionsCorticosteroids may prevent parturition and surgical HBPN attacks in some patients. Diverse surgeries, anesthesia, and childbirth frequently trigger HBPN attacks.

Indexed as

ImmunotherapyPostpartum PeriodAdolescentAdultAgedBrachial Plexus NeuritisBrachial Plexus NeuropathiesCesarean SectionFemaleHumansLaminectomyMaleMiddle AgedThyroidectomy

Identifiers

PMID23042485
PMCPMC3528817
OpenAlexW1693297962

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.