ArticleNature methods2012
Iterative plug-and-play methodology for constructing and modifying synthetic gene networks.
Article in Nature methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- The p40 fusion domain as a scaffold for producing functional inclusion bodies.Applied microbiology and biotechnology · 2026Article
- Engineered live bacteria as disease detection and diagnosis tools.Journal of biological engineering · 2023Review
- Unbalanced response to growth variations reshapes the cell fate decision landscape.Nature chemical biology · 2023Article
- Article
- Ratiometric control of cell phenotypes in monostrain microbial consortia.Journal of the Royal Society, Interface · 2022Article
- Rational design of complex phenotype via network models.PLoS computational biology · 2021Article
- A rationally engineered decoder of transient intracellular signals.Nature communications · 2021Article
- Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch.Molecular systems biology · 2020Article
- Topology-dependent interference of synthetic gene circuit function by growth feedback.Nature chemical biology · 2020Article
- Synthetic biology for improving cell fate decisions and tissue engineering outcomes.Emerging topics in life sciences · 2019Article
- Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset.Nucleic acids research · 2019Article
- Towards an Aspect-Oriented Design and Modelling Framework for Synthetic Biology.Processes (Basel, Switzerland) · 2018Article
- Bottom-up approaches in synthetic biology and biomaterials for tissue engineering applications.Journal of industrial microbiology & biotechnology · 2018Article
- Design of Adjacent Transcriptional Regions to Tune Gene Expression and Facilitate Circuit Construction.Cell systems · 2018Article
- Development of novel metabolite-responsive transcription factors via transposon-mediated protein fusion.Protein engineering, design & selection : PEDS · 2018Article
- Engineering a living biomaterial via bacterial surface capture of environmental molecules.Synthetic biology (Oxford, England) · 2018Article
- Computing with biological switches and clocks.Natural computing · 2018Article
- Article
- Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials.Journal of visualized experiments : JoVE · 2017Article
- Development of a genetically programed vanillin-sensing bacterium for high-throughput screening of lignin-degrading enzyme libraries.Biotechnology for biofuels · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We present a methodology for the design, construction and modification of synthetic gene networks. This method emphasizes post-assembly modification of constructs based on network behavior, thus facilitating iterative design strategies and rapid tuning and repurposing of gene networks. The ease of post-construction modification afforded by this approach and the ever-increasing repository of components within the framework will help accelerate the development of functional genetic circuits for synthetic biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.