ArticleAsian journal of andrology2012
Testosterone is negatively associated with the severity of coronary atherosclerosis in men.
Article in Asian journal of andrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Association of testosterone with myocardial infarction and severity of coronary artery disease among male patients.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- The influence of testosterone on the risk of cardiovascular events after percutaneous coronary intervention.Frontiers in cardiovascular medicine · 2022Article
- Heterogeneity and Dynamics of Vasculature in the Endocrine System During Aging and Disease.Frontiers in physiology · 2021Review
- Testosterone replacement therapy and cardiovascular risk.Nature reviews. Cardiology · 2019Review
- Testosterone and the Heart.European cardiology · 2019Review
- Testosterone, myocardial function, and mortality.Heart failure reviews · 2018Review
- MECHANISMS IN ENDOCRINOLOGY: The sexually dimorphic role of androgens in human metabolic disease.European journal of endocrinology · 2017Review
- Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women.International journal of endocrinology · 2017Article
- Association of admission testosterone level with ST-segment resolution in male patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.Basic and clinical andrology · 2017Article
- Testosterone as a marker of coronary artery disease severity in middle aged males.Indian heart journal · 2016Observational
- Testosterone Replacement Therapy and Mortality in Older Men.Drug safety · 2016Review
- The Association between Androgenic Hormone Levels and the Risk of Developing Coronary Artery Disease (CAD).Iranian journal of public health · 2016Article
- Reactive oxygen species: players in the cardiovascular effects of testosterone.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Androgen receptor roles in insulin resistance and obesity in males: the linkage of androgen-deprivation therapy to metabolic syndrome.Diabetes · 2014Review
- Testosterone deficiency, cardiac health, and older men.International journal of endocrinology · 2014Review
- Testosterone and the cardiovascular system: a comprehensive review of the clinical literature.Journal of the American Heart Association · 2013Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to determine whether plasma testosterone is associated with the severity of coronary atherosclerosis in a group of 803 men who underwent elective coronary angiography. Testosterone levels were measured in 803 male patients who were categorized into three groups according to testosterone level tertiles. All patients underwent elective coronary angiography, and the severity of coronary artery disease (CAD) was determined by the Gensini score. Moreover, patients were classified into two groups according to Gensini scores (score ≤26 and score >26) using the median values as cutoff points. The plasma testosterone levels were measured by an ELISA kit. The level of testosterone was negatively associated with the Gensini score (r=-0.188; P=0.000). A multiple linear regression analysis revealed that testosterone was an independent risk factor for the Gensini score (β=-0.110; P=0.002) after adjusting for confounding covariates. In a multivariate logistic regression model, the severity of CAD was shown to be significantly lower in the third tertile (highest) of testosterone compared to the first tertile (lowest) of testosterone (odds ratio (OR)=0.465; 95% confidence interval (CI): 0.327-0.662; P=0.000). In this study, patients with lower testosterone levels had higher Gensini scores in a group of 803 men who underwent elective coronary angiography. Additional studies are needed to clarify the direction of causality and possible underlying mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.