ArticleAsian journal of andrology2012
Genetic polymorphisms in HIF1A are associated with prostate cancer risk in a Chinese population.
Article in Asian journal of andrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 10 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 10 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis.BMC cancer · 2019Pooled it
- Association of hypoxia-inducible factor-1α (HIF1α) 1790G/A gene polymorphism with renal cell carcinoma and prostate cancer susceptibility: a meta-analysis.BMC medical genetics · 2019Pooled it
- Association between HIF1A rs11549465 polymorphism and risk of prostate cancer: a meta-analysis.Oncotarget · 2017Pooled it
- Pooled it
- Hypoxia-inducible factor-1α (HIF-1α) C1772T polymorphism significantly contributes to the risk of malignancy from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- The association between HIF-1α polymorphism and cancer risk: a systematic review and meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Clinicopathological significance of hypoxia-inducible factor-1 alpha polymorphisms in cancers: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Pooled it
- Pooled it
- Association between HIF1A P582S and A588T polymorphisms and the risk of urinary cancers: a meta-analysis.PloS one · 2013Pooled it
- Interaction Between Hypoxia-Inducible Factor 1-alpha Gene Polymorphism and Helicobacter pylori Infection on Gastric Cancer in a Chinese Tibetan Population.Biochemical genetics · 2025Article
- Genetic variants in hypoxia-inducible factor pathway are associated with colorectal cancer risk and immune infiltration.Journal of cellular and molecular medicine · 2024Article
- Sestrin2 in cancer: a foe or a friend?Biomarker research · 2022Review
- Bioinformatics and immunohistochemistry analyses of expression levels and clinical significance of CXCL2 and TANs in an oral squamous cell carcinoma tumor microenvironment ofOncology letters · 2021Article
- Article
- Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer.Turkish archives of otorhinolaryngology · 2018Article
- HIF-1A gene polymorphisms and its protein level in patients with rheumatoid arthritis: a case-control study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Article
- Association Between 12 Polymorphisms of VEGF/Hypoxia/Angiogenesis Pathway Genes and Risk of Urogenital Carcinomas: A Meta-Analysis Based on Case-Control Studies.Frontiers in physiology · 2018Article
- HIF1A gene polymorphisms and human diseases: Graphical review of 97 association studies.Genes, chromosomes & cancer · 2017Review
- [Association of Indoor Air Pollution, Single Nucleotide Polymorphism of HIF-1α Gene with Susceptibility to Lung Cancer in Han Population in Fujian Province].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypoxia-inducible factor-1α (HIF-1α) plays an important role in regulating angiogenesis, which is essential for tumor growth and metastasis. Genetic variations of HIF1A (coding HIF-1α) have been shown to influence an individual's susceptibility to many human tumors; however, evidence on associations between HIF1A single-nucleotide polymorphisms (SNPs) and prostate cancer (PCa) risk is conflicting. We genotyped three potentially functional polymorphisms in HIF1A (rs11549465, rs11549467 and rs2057482) using the TaqMan method and assessed their associations with PCa risk in a case-control study of 662 PCa patients and 716 controls in a Chinese Han population. Compared with rs11549467 GG genotype, the variant genotypes GA+AA had a significantly increased PCa risk (adjusted odds ratio (OR)=1.70; 95% confidence interval (CI)=1.06-2.72), particularly among older patients (OR=2.01; 95%CI=1.05-3.86), smokers (OR=2.06; 95%CI=1.07-3.99), never drinkers (OR=2.16; 95%CI=1.20-3.86) and patients without a family history of cancer (OR=1.71; 95%CI=1.02-2.89). Furthermore, patients with rs11549467 variant genotypes were associated with a higher Gleason score (OR=2.14; 95%CI=1.22-3.75). No altered PCa risk was associated with the rs11549465 and rs2057482 polymorphism. However, the combined variant genotypes of rs2057482 and rs11549467 were associated with increased PCa risk (OR=2.10; 95%CI=1.23-3.57 among subjects carrying three or more risk alleles). These results suggest that HIF1A polymorphisms may impact PCa susceptibility and progression in the Chinese Han population.
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