Lethal H5N1 influenza viruses are not resistant to interferon action in human, simian, porcine or chicken cells.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

1. Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates.PLoS pathogens · 2022
   Article
2. Impact of Individual Viral Gene Segments from Influenza A/H5N8 Virus on the Protective Efficacy of Inactivated Subtype-Specific Influenza Vaccine.Pathogens (Basel, Switzerland) · 2021
   Article
3. Highly Pathogenic H5N1 Influenza A Virus Spreads Efficiently in Human Primary Monocyte-Derived Macrophages and Dendritic Cells.Frontiers in immunology · 2018
   Article
4. Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses.Journal of virology · 2015
   Article
5. Twenty-five years of type I interferon-based treatment: a critical analysis of its therapeutic use.Cytokine & growth factor reviews · 2015
   Review
6. In vivo assessment of NS1-truncated influenza virus with a novel SLSYSINWRH motif as a self-adjuvanting live attenuated vaccine.PloS one · 2015
   Article
7. Novel avian influenza A (H7N9) virus induces impaired interferon responses in human dendritic cells.PloS one · 2014
   Article
8. Changes in the NS1 gene of avian influenza viruses isolated in Thailand affect expression of type I interferon in primary chicken embryonic fibroblast cells.Indian journal of virology : an official organ of Indian Virological Society · 2013
   Article

Corrections and comments

• Comment on
  Lethal H5N1 influenza viruses escape host anti-viral cytokine responses.2002

Authors and funding

6 authors at 3 institutions in 1 country.

Funding

Abstract

PubMed holds no abstract for this paper.

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