ArticleNature medicine2012
Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression.
Article in Nature medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03821311 (Investigating the Effect of Nasal High Flow Oxygen Therapy on Regional Lung Function), which is not on this map. Cited by 418 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Effect of Nasal High Flow Oxygen Therapy on Regional Lung Function
Who cites it
418 citing papers in PubMed, 1 synthesis or guideline pooled it, 785 citations in OpenAlex.
- Pooled it
- Feasibility of opportunistic screening for preserved ratio impaired spirometry using chest radiography-based deep learning models.European journal of radiology open · 2026Article
- Dual-respiratory-phase low-dose quantitative CT for assessing COPD severity.Radiologie (Heidelberg, Germany) · 2026Article
- CT-based pulmonary vascular pruning and emphysema: clinical correlations and prognostic impacts in COPD.European radiology · 2026Article
- Imaging Markers of Chronic Obstructive Pulmonary Disease on Computed Tomography of the Lungs: a Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Segmentation-based deep learning emphysema quantification using chest CT: improved accuracy and robustness vs LAA-950.European radiology · 2026Article
- Computed tomography-derived pulmonary blood volume distribution may be modifiable in asthma.ERJ open research · 2026Article
- Chest CT imaging toward personalized management of chronic obstructive pulmonary disease, asthma, and bronchiectasis: pulmonologist perspectives.Japanese journal of radiology · 2026Review
- Bronchial Wall T2-Weighted MRI Signal: An Emerging Investigational Non-Ionizing Imaging Biomarker in Severe Asthma.Biomedicines · 2026Article
- Seeing is believing-on the utility of CT in phenotyping chronic obstructive pulmonary disease.The British journal of radiology · 2026Review
- Precision treatment of COPD based on novel imaging phenotypes: a treatable traits approach.Respiratory research · 2026Review
- Comparison of phase-resolved functional lung (PREFUL) MRI and CT parametric response mapping (PRM) in COSYCONET COPD.European radiology · 2026Article
- Quantitative lung tissue functional analysis for pulmonary adverse event risk assessment prior to thoracic radiotherapy.Physics and imaging in radiation oncology · 2026Article
- From Airways to Arteries: Dissecting the Inflammatory Mechanisms of Pulmonary Vascular Remodeling in a Murine Model of Chronic Airway Inflammation.Biomedicines · 2026Article
- Article
- Parameter response mapping does not enhance the correlations of conventional CT quantitative metrics with lung function and subjective symptoms in chronic obstructive pulmonary disease.Quantitative imaging in medicine and surgery · 2026Article
- Assessment of CT quantitative characteristics derived from CT in connective tissue disease-associated interstitial lung disease.Journal of thoracic disease · 2026Article
- Label-Free Lung MRI Segmentation via Misalignment-Aware Diffusion Translation.Journal of imaging informatics in medicine · 2026Article
- Radiomic analysis of computed tomography scans in COPD patients relates to different clinical and biological features, and identifies different lung function trajectories during follow-up.ERJ open research · 2026Article
- Comparison of Signal- and Volume-Based Ventilation-Weighted Assessment Using 3D FLORET UTE MRI in Patients With Various Pulmonary Disease.Magnetic resonance in medicine · 2026Article
358 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Chronic obstructive pulmonary disease (COPD) is increasingly being recognized as a highly heterogeneous disorder, composed of varying pathobiology. Accurate detection of COPD subtypes by image biomarkers is urgently needed to enable individualized treatment, thus improving patient outcome. We adapted the parametric response map (PRM), a voxel-wise image analysis technique, for assessing COPD phenotype. We analyzed whole-lung computed tomography (CT) scans acquired at inspiration and expiration of 194 individuals with COPD from the COPDGene study. PRM identified the extent of functional small airways disease (fSAD) and emphysema as well as provided CT-based evidence that supports the concept that fSAD precedes emphysema with increasing COPD severity. PRM is a versatile imaging biomarker capable of diagnosing disease extent and phenotype while providing detailed spatial information of disease distribution and location. PRM's ability to differentiate between specific COPD phenotypes will allow for more accurate diagnosis of individual patients, complementing standard clinical techniques.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.