ArticleEukaryotic cell2012
Deletion of the fungal gene soft disrupts mutualistic symbiosis between the grass endophyte Epichloë festucae and the host plant.
Article in Eukaryotic cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 49 citations in OpenAlex.
- Cdc25-Mediated Activation of the Small GTPase RasB Is Essential for Hyphal Fusion and Symbiotic Infection of Epichloë festucae.Molecular plant pathology · 2026Article
- Comparative genomics of Metarhizium brunneum strains V275 and ARSEF 4556: unraveling intraspecies diversity.G3 (Bethesda, Md.) · 2024Article
- Developing robust quantitative PCR primers for comparative biomass analysis of Tall Fescue (Festuca arundinacea) and its Epichloë endophyte.microPublication biology · 2024Article
- Dissection of the epoxyjanthitrem pathway inFrontiers in fungal biology · 2022Article
- Article
- The role of vegetative cell fusions in the development and asexual reproduction of the wheat fungal pathogen Zymoseptoria tritici.BMC biology · 2020Article
- Fungal Endophyte Colonization Patterns Alter Over Time in the Novel Association BetweenFrontiers in plant science · 2020Article
- VelA and LaeA are Key Regulators ofMicroorganisms · 2019Article
- Integration of Self and Non-self Recognition Modulates Asexual Cell-to-Cell Communication inGenetics · 2019Article
- BiFC-based visualisation system reveals cell fusion morphology and heterokaryon incompatibility in the filamentous fungus Aspergillus oryzae.Scientific reports · 2018Article
- Article
- Molecular Mechanisms Regulating Cell Fusion and Heterokaryon Formation in Filamentous Fungi.Microbiology spectrum · 2017Review
- New insights from an old mutant: SPADIX4 governs fruiting body development but not hyphal fusion in Sordaria macrospora.Molecular genetics and genomics : MGG · 2017Article
- An Epichloë festucae homologue of MOB3, a component of the STRIPAK complex, is required for the establishment of a mutualistic symbiotic interaction with Lolium perenne.Molecular plant pathology · 2016Article
- Global transcriptome changes in perennial ryegrass during early infection by pink snow mould.Scientific reports · 2016Article
- Article
- Vegetative hyphal fusion and subsequent nuclear behavior in Epichloë grass endophytes.PloS one · 2015Article
- Fungal communication requires the MAK-2 pathway elements STE-20 and RAS-2, the NRC-1 adapter STE-50 and the MAP kinase scaffold HAM-5.PLoS genetics · 2014Article
- HAM-5 functions as a MAP kinase scaffold during cell fusion in Neurospora crassa.PLoS genetics · 2014Article
- PRO40 is a scaffold protein of the cell wall integrity pathway, linking the MAP kinase module to the upstream activator protein kinase C.PLoS genetics · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyphal anastomosis, or vegetative hyphal fusion, establishes the interconnection of individual hyphal strands into an integrated network of a fungal mycelium. In contrast to recent advances in the understanding of the molecular basis for hyphal anastomosis, knowledge of the physiological role of hyphal anastomosis in the natural habitats of filamentous fungi is still very limited. To investigate the role of hyphal anastomosis in fungal endophyte-plant interactions, we generated mutant strains lacking the Epichloë festucae soft (so) gene, an ortholog of the hyphal anastomosis gene so in the endophytic fungus E. festucae. The E. festucae Δso mutant strains grew similarly to the wild-type strain in culture but with reduced aerial hyphae and completely lacked hyphal anastomosis. The most striking phenotype of the E. festucae Δso mutant strain was that it failed to establish a mutualistic symbiosis with the tall fescue plant host (Lolium arundinaceum); instead, it killed the host plant within 2 months after the initial infection. Microscopic examination revealed that the death of the tall fescue plant host was associated with the distortion and disorganization of plant cells. This study suggests that hyphal anastomosis may have an important role in the establishment/maintenance of fungal endophyte-host plant mutualistic symbiosis.
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