ArticleThe Pediatric infectious disease journal2013
Risk factors for invasive candidiasis in infants >1500 g birth weight.
Article in The Pediatric infectious disease journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Shorter versus longer duration antibiotic regimens for treatment of suspected neonatal sepsis.The Cochrane database of systematic reviews · 2024Pooled it
- [Value of targeted next-generation sequencing in pathogen detection for neonates with respiratory distress syndrome: a prospective randomized controlled trial].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Trial
- Dietary Supplementation With Medium-Chain Triglycerides Reduces Candida Gastrointestinal Colonization in Preterm Infants.The Pediatric infectious disease journal · 2019Trial
- Antimicrobial-associated adverse events in neonates: an integrated literature review and FAERS pharmacovigilance analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Neonatal Candidemia: Clinical Characteristics and Predictors of 28-Day Mortality.Journal of fungi (Basel, Switzerland) · 2026Article
- Addressing the silent threat: managing invasiveFrontiers in pediatrics · 2025Review
- The Role of Rotational Thromboelastometry in Early Detection of the Hemostatic Derangements in Neonates with Systemic Candida Infection.Journal of fungi (Basel, Switzerland) · 2024Article
- Invasive Candida Infections in Neonatal Intensive Care Units: Risk Factors and New Insights in Prevention.Pathogens (Basel, Switzerland) · 2024Review
- Shorter versus longer duration antibiotic regimens for treatment of culture-positive neonatal sepsis.The Cochrane database of systematic reviews · 2024Article
- End-organ damage from neonatal invasive fungal infection: a 14-year retrospective study from a tertiary center in China.BMC infectious diseases · 2024Article
- Invasive fungal infections in neonates: a review.Pediatric research · 2022Review
- Antibiotic-induced depletion ofFrontiers in cellular and infection microbiology · 2022Article
- Candida albicans-associated sepsis in a pre-term neonatal rhesus macaque (Macaca mulatta).Journal of medical primatology · 2019Article
- Antimicrobial Stewardship in the Neonatal Intensive Care Unit: An Update.Current pediatric reviews · 2019Review
- [Research advances in rational use of antibiotics in neonates].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- Retrospective surveillance of antibiotic use in maternity wards and neonatal intensive care units in Saint Petersburg, Russia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Changes in the epidemiological landscape of invasive candidiasis.The Journal of antimicrobial chemotherapy · 2018Review
- Particularities of the management and the treatment in a rare sepsis with Candida tropicalis of a Collodion baby: Case report.Medicine · 2017Article
- Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children.Journal of the Pediatric Infectious Diseases Society · 2017Review
- Neonatal Candidiasis: New Insights into an Old Problem at a Unique Host-Pathogen Interface.Current fungal infection reports · 2015Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundWe describe the incidence, risk factors and outcomes of invasive candidiasis in infants >1500 g birth weight.
methodsWe conducted a retrospective cohort study of infants >1500 g birth weight discharged from 305 neonatal intensive care units in the Pediatrix Medical Group from 2001 to 2010. Using multivariable logistic regression, we identified risk factors for invasive candidiasis.
resultsInvasive candidiasis occurred in 330 of the 530,162 (0.06%) infants. These were documented from positive cultures from ≥1 of these sources: blood (n = 323), cerebrospinal fluid (n = 6) or urine from catheterization (n = 19). Risk factors included day of life >7 (odds ratio [OR]: 25.2; 95% confidence interval: 14.6-43.3), vaginal birth (OR: 1.6 [1.2-2.3]), exposure to broad-spectrum antibiotics (OR: 1.6 [1.1-2.4]), central venous line (OR: 1.8 [1.3-2.6]) and platelet count <50,000/mm (OR: 3.7 [2.1-6.7]). All risk factors had poor sensitivities, low positive likelihood ratios and low positive predictive values. The combination of broad-spectrum antibiotics and low platelet count had the highest positive likelihood ratio (46.2), but the sensitivity of this combination was only 4%. Infants with invasive candidiasis had increased mortality (OR: 2.2 [1.3-3.6]).
conclusionsInvasive candidiasis is uncommon in infants >1500 g birth weight. Infants at greatest risk are those exposed to broad-spectrum antibiotics and with platelet counts of <50,000/mm(3).
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