ArticleThe Indian journal of medical research2012
Adverse drug reactions & their risk factors among Indian ambulatory elderly patients.
Article in The Indian journal of medical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Antidepressant use and risk of coronary heart disease: meta-analysis of observational studies.British journal of clinical pharmacology · 2014Pooled it
- A Retrospective Observational Study of Adverse Drug Reactions (ADR) Reported to ADR Monitoring Centre from 2010 to 2020.Current drug safety · 2025Observational
- Study of pattern & distribution of adverse drug reactions in acute coronary syndrome patients in a tertiary care hospital.The Indian journal of medical research · 2022Article
- Adverse Drug Reactions and Potentially Inappropriate Medication in Older Patients: Analysis of the Portuguese Pharmacovigilance Database.Journal of clinical medicine · 2022Article
- A machine learning-based risk warning platform for potentially inappropriate prescriptions for elderly patients with cardiovascular disease.Frontiers in pharmacology · 2022Article
- Issues and challenges of polypharmacy in the elderly: A review of contemporary Indian literature.Journal of family medicine and primary care · 2021Review
- Prevalence, characteristics and predicting risk factors of adverse drug reactions among hospitalized older adults: A systematic review and meta-analysis.SAGE open medicine · 2021Review
- Assessment of drug therapy problem and associated factors among adult hypertensive patients at Ayder comprehensive specialized hospital, Northern Ethiopia.African health sciences · 2019Article
- The combined effect of Trigonella foenum seeds and Coriandrum sativum leaf extracts in alloxan-induced diabetes mellitus wistar albino rats.Bioinformation · 2019Article
- Assessment of hepatotoxicity of first-line anti-tuberculosis drugs on Wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Adverse drug reactions experience in a teaching hospital in Jordan.International journal of clinical pharmacy · 2015Observational
- Comparative study on drug safety surveillance between medical students of Malaysia and Nigeria.Therapeutics and clinical risk management · 2015Article
- Antidiabetic activity of polyherbal formulation in streptozotocin - nicotinamide induced diabetic wistar rats.Journal of traditional and complementary medicine · 2014Article
- Promoting drug safety in elderly--needs a proactive approach.The Indian journal of medical research · 2012Article
- An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital.Perspectives in clinical researchArticle
- Iatrogenesis: A review on nature, extent, and distribution of healthcare hazards.Journal of family medicine and primary careReview
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectivesSeveral studies have reported adverse drug events ranging from 5 to 35 per cent in all age group from outpatient setting. However, adverse drug reactions (ADRs) particularly among a large sample of ambulatory elderly patients in India has not been reported. This study has attempted to identify ADRs and assessed their causality, preventability and severity, and also their risk factors in Indian ambulatory elderly patients.
methodsA 2 year long term prospective study included 4005 ambulatory elderly patients (60 yr or above; either sex) at a public teaching hospital. Suspected ADRs were assessed for causality, preventability and severity using Naranjo's probability scale, modified Schumock and Thornton's criteria, and modified Hartwig's criteria, respectively.
resultsOf the total 4005 prescriptions, 406 were identified with ADRs, giving the occurrence of 10 per cent ADRs in elderly. The total number of ADRs was 422 in 406 prescriptions. Type A ADRs accounted for 46 per cent of the total ADRs. Majority of the ADRs (88.6%) were classified as 'probable'. The definitely preventable reactions were 22 per cent. The percentage of moderate reaction was 16 per cent. Only 1.6 per cent ADRs was severe in nature. The most common type of ADR was peripheral oedema. The most commonly offending class of drug was cardiovascular drugs (57.6%). Using logistic regression analysis, the risk factors which contributed to ADRs were age above 80 yr (OR=1.7), prescription of multiple drugs (OR=1.8), longer duration of treatment (OR=2.28) and multiple diagnoses (OR=1.8). INTERPRETATION &
conclusionsIn this study, 10 per cent ambulatory elderly patients were found to have ADRs. This indicates that the elderly patients should be closely monitored for ADRs, to avoid clinically significant harmful consequences. The awareness of risk factors of ADRs would help physicians to identify elderly patients with greater risk of ADRs and, therefore, might benefit from ADRs monitoring and reporting programme.
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23041733PMC3510886W2130859944What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.