ReviewFrontiers in neuroendocrinology2012
Gonadotropin-releasing hormone plasticity: a comparative perspective.
Review in Frontiers in neuroendocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 89 citations in OpenAlex.
- Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses.Equine veterinary journal · 2026Article
- Molecular characterization of circannual interval timing in the preoptic area and anteroventral periventricular nucleus in the Djungarian hamster (Phodopus sungorus).Journal of neuroendocrinology · 2026Article
- Exploring the Sex-Differentiated Transcription of GnRH1/GnRHR1 Signaling in Hamster.Life (Basel, Switzerland) · 2026Article
- cba-miR-222-3p involved in photoperiod-induced apoptosis in testes of striped hamsters by targeting TRAF7.Integrative zoology · 2025Article
- Timing mismatches, carryover effects, and the role of neuroendocrine mechanisms in determining birds' responses to environmental change.Journal of neuroendocrinology · 2025Review
- Hypotheses in light detection by vertebrate ancient opsin in the bird brain.Journal of neuroendocrinology · 2025Review
- Down regulation of the c-Fos/MAP kinase signaling pathway during learning memory processes coincides with low GnRH levels in aluminum chloride-induced Alzheimer's male rats.Molecular biology reports · 2024Article
- Article
- Steroid-dependent plasticity in the song control system: Perineuronal nets and HVC neurogenesis.Frontiers in neuroendocrinology · 2023Review
- Article
- Shuttle Transfer of mRNA TranscriptsFrontiers in veterinary science · 2022Article
- Identification and Characterization of Hypothalamic Alternative Splicing Events and Variants in Ovine Fecundity-Related Genes.Animals : an open access journal from MDPI · 2020Article
- Mechanistic target of rapamycin (mTOR) implicated in plasticity of the reproductive axis during social status transitions.General and comparative endocrinology · 2019Article
- The Value of Comparative Animal Research: Krogh's Principle Facilitates Scientific Discoveries.Policy insights from the behavioral and brain sciences · 2018Article
- Flexible clock systems: adjusting the temporal programme.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Neural control of daily and seasonal timing of songbird migration.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Predictability of Precipitation Over the Conterminous U.S. Based on the CMIP5 Multi-Model Ensemble.Scientific reports · 2016Article
- Genetic variation in total number and locations of GnRH neurons identified using in situ hybridization in a wild-source population.Journal of experimental zoology. Part A, Ecological genetics and physiology · 2016Article
- Social Transitions Cause Rapid Behavioral and Neuroendocrine Changes.Integrative and comparative biology · 2015Review
- Gene expression profiling of brains from bovine spongiform encephalopathy (BSE)-infected cynomolgus macaques.BMC genomics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Gonadotropin-releasing hormone 1 (GnRH1) is a key regulator of the reproductive neuroendocrine system in vertebrates. Recent developments have suggested that GnRH1 neurons exhibit far greater plasticity at the cellular and molecular levels than previously thought. Furthermore, there is growing evidence that sub-populations of GnRH1 neurons in the preoptic area are highly responsive to specific environmental and hormonal conditions. In this paper we discuss findings that reveal large variation in GnRH1 mRNA and protein expression that are regulated by social cues, photoperiod, and hormonal feedback. We draw upon studies using histochemistry and immediate early genes (e.g., c-FOS/ZENK) to illustrate that specific groups of GnRH1 neurons are topographically organized. Based on data from diverse vertebrate species, we suggest that GnRH1 expression within individuals is temporally dynamic and this plasticity may be evolutionarily conserved. We suggest that the plasticity observed in other neuropeptide systems (i.e. kisspeptin) may have evolved in a similar manner.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.