ArticleCell reports2012
Programmed cell-to-cell variability in Ras activity triggers emergent behaviors during mammary epithelial morphogenesis.
Article in Cell reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- DNA-programmed cell assembly: from cells, tissues to organoids.Frontiers in bioengineering and biotechnology · 2025Review
- Controlling Cell Interactions with DNA Directed Assembly.Advanced healthcare materials · 2024Review
- Quantitative insights in tissue growth and morphogenesis with optogenetics.Physical biology · 2023Review
- Expanding the boundaries of synthetic development.Developmental biology · 2021Review
- Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes.Journal of cell science · 2019Article
- HDAC7-mediated control of tumour microenvironment maintains proliferative and stemness competence of human mammary epithelial cells.Molecular oncology · 2019Article
- From single cells to tissue self-organization.The FEBS journal · 2019Review
- Minimal Network Topologies for Signal Processing during Collective Cell Chemotaxis.Biophysical journal · 2018Article
- Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme.Developmental cell · 2018Article
- Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.Developmental cell · 2017Article
- Epithelial cell extrusion: Pathways and pathologies.Seminars in cell & developmental biology · 2017Review
- Variation is function: Are single cell differences functionally important?: Testing the hypothesis that single cell variation is required for aggregate function.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Coupling between apical tension and basal adhesion allow epithelia to collectively sense and respond to substrate topography over long distances.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Programmed synthesis of three-dimensional tissues.Nature methods · 2015Article
- DNA nanotechnology from the test tube to the cell.Nature nanotechnology · 2015Review
- Formation of spatially and geometrically controlled three-dimensional tissues in soft gels by sacrificial micromolding.Tissue engineering. Part C, Methods · 2015Article
- A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer.Cell cycle (Georgetown, Tex.) · 2015Article
- Efficient targeting of fatty-acid modified oligonucleotides to live cell membranes through stepwise assembly.Biomacromolecules · 2014Article
- Three-dimensional organotypic culture: experimental models of mammalian biology and disease.Nature reviews. Molecular cell biology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Variability in signaling pathway activation between neighboring epithelial cells can arise from local differences in the microenvironment, noisy gene expression, or acquired genetic changes. To investigate the consequences of this cell-to-cell variability in signaling pathway activation on coordinated multicellular processes such as morphogenesis, we use DNA-programmed assembly to construct three-dimensional MCF10A microtissues that are mosaic for low-level expression of activated H-Ras. We find two emergent behaviors in mosaic microtissues: cells with activated H-Ras are basally extruded or lead motile multicellular protrusions that direct the collective motility of their wild-type neighbors. Remarkably, these behaviors are not observed in homogeneous microtissues in which all cells express the activated Ras protein, indicating that heterogeneity in Ras activity, rather than the total amount of Ras activity, is critical for these processes. Our results directly demonstrate that cell-to-cell variability in pathway activation within local populations of epithelial cells can drive emergent behaviors during epithelial morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.