ArticleJournal of controlled release : official journal of the Controlled Release Society2012
Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Next generation protein-corrole bio-assemblies provide effective tumoricidal treatment in a metastatic triple-negative breast cancer model.bioRxiv : the preprint server for biology · 2026Article
- Nano-bioparticles: Fighting cancer with targeted nanotherapy.Open access government · 2026Article
- Article
- Review
- Biomedical Applications of Translational Optical Imaging: From Molecules to Humans.Molecules (Basel, Switzerland) · 2021Review
- Porphyrinoid Drug Conjugates.Chem · 2020Article
- The photocytotoxicity effect of cationic sulfonated corrole towards lung cancer cells: in vitro and in vivo study.Lasers in medical science · 2019Article
- Photophysical properties and singlet oxygen generation ofRSC advances · 2019Article
- Effective photo-enhancement of cellular activity of fluorophore-octaarginine antisense PNA conjugates correlates with singlet oxygen formation, endosomal escape and chromophore lipophilicity.Scientific reports · 2018Article
- Ultrafast Dynamics of Sb-Corroles: A Combined Vis-Pump Supercontinuum Probe and Broadband Fluorescence Up-Conversion Study.Molecules (Basel, Switzerland) · 2017Article
- Fighting Cancer with Corroles.Chemical reviews · 2017Review
- DNA-Binding, Photocleavage, and Photodynamic Anti-cancer Activities of Pyridyl Corroles.The Journal of membrane biology · 2016Article
- Article
- Ultrafast electronic and vibrational dynamics in brominated aluminum corroles: Energy relaxation and triplet formation.Structural dynamics (Melville, N.Y.) · 2016Article
- A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Computational predictions of corroles as a class of Hsp90 inhibitors.Molecular bioSystems · 2015Article
- An in vitro enzymatic assay to measure transcription inhibition by gallium(III) and H3 5,10,15-tris(pentafluorophenyl)corroles.Journal of visualized experiments : JoVE · 2015Article
- Development of adenovirus capsid proteins for targeted therapeutic delivery.Therapeutic delivery · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The tumor-targeted corrole particle, HerGa, displays preferential toxicity to tumors in vivo and can be tracked via fluorescence for simultaneous detection, imaging, and treatment. We have recently uncovered an additional feature of HerGa in that its cytotoxicity is enhanced by light irradiation. In the present study, we have elucidated the cellular mechanisms for HerGa photoexcitation-mediated cell damage using fluorescence optical imaging. In particular, we found that light irradiation of HerGa produces singlet oxygen, causing mitochondrial damage and cytochrome c release, thus promoting apoptotic cell death. An understanding of the mechanisms of cell death induced by HerGa, particularly under conditions of light-mediated excitation, may direct future efforts in further customizing this nanoparticle for additional therapeutic applications and enhanced potency.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.