ReviewExperimental and molecular pathology2012
Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.
Review in Experimental and molecular pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Exploring the Immunomodulatory Role of Forkhead Box Protein 3 (FOXP3) in the Pathophysiology of Neuropsychiatric Disorders.Molecular neurobiology · 2025Review
- Targeting post-translational modifications of Foxp3: a new paradigm for regulatory T cell-specific therapy.Frontiers in immunology · 2023Review
- A Structure-Guided Delineation of FOXP3 Regulation Mechanism in IPEX.Advances in experimental medicine and biology · 2021Article
- Activation ofFrontiers in immunology · 2021Article
- Regulatory T Cells: Regulation of Identity and Function.Frontiers in immunology · 2021Review
- Case Report:Frontiers in immunology · 2021Article
- FoxP3 in TClinical and experimental immunology · 2020Review
- Large-Scale Generation of Human Allospecific Induced Tregs With Functional Stability for Use in Immunotherapy in Transplantation.Frontiers in immunology · 2020Article
- Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice.Biological research · 2019Article
- Foxp3 Post-translational Modifications and Treg Suppressive Activity.Frontiers in immunology · 2019Review
- Tumor-infiltrating regulatory T cells: origins and features.American journal of clinical and experimental immunology · 2018Review
- The regulation of immune tolerance by FOXP3.Nature reviews. Immunology · 2017Review
- Proinflammatory cytokine interferon-γ and microbiome-derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease.Clinical and experimental immunology · 2017Article
- IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3.Scientific reports · 2015Article
- Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.The Journal of biological chemistry · 2015Article
- Ubiquitin-dependent regulation of Foxp3 and Treg function.Immunological reviews · 2015Review
- Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors.Molecular and cellular endocrinology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Regulatory T (Treg) cells are essential in preventing the host from developing certain autoimmune diseases and limiting excessive immune responses against pathogens. The normal function of most Treg cells requires sustained expression of functional FOXP3, a member of the FOXP family transcription factors. FOXP3 is distinct from other subfamily members because of its unique proline rich amino (N)-terminal domain. Mutations in this region are occasionally identified in certain patients with X-linked autoimmunity-allergic dysregulation syndrome (XLAAD) and similar mutations also increase susceptibility of autoimmune diseases in rodent models. Previous analyses of the FOXP3 N-terminal domain revealed a role in nuclear import, interaction with other transcription factors, and as sites of specific post-translational modifications of FOXP3 that contribute to FOXP3 stability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.