ArticleImmunity2012
The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation.
Article in Immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Development of αβ and γδ T Cells in the Thymus and Methods of Analysis.International journal of molecular sciences · 2025Review
- A multimorphic variant in ThPOK causes an inborn error of immunity with T cell defects and fibrosis.The Journal of experimental medicine · 2025Article
- Automated high-throughput profiling of single-cell total transcriptome with scComplete-seq.Nucleic acids research · 2025Article
- The dual nature of TFEBS letters · 2025Review
- Generation of Retrogenic Mice to Investigate T Cell Development.Methods in molecular biology (Clifton, N.J.) · 2023Article
- NuRD complex recruitment to Thpok mediates CD4Science immunology · 2022Article
- The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8ααNature immunology · 2022Article
- Article
- ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells.Frontiers in immunology · 2021Review
- An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.Immunity · 2020Article
- The multi-faceted functioning portrait of LRF/ZBTB7A.Human genomics · 2019Review
- Vertebrate GAF/ThPOK: emerging functions in chromatin architecture and transcriptional regulation.Cellular and molecular life sciences : CMLS · 2018Review
- A STAT3-dependent transcriptional circuitry inhibits cytotoxic gene expression in T cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Zbtb7a induction in alveolar macrophages is implicated in anti-HLA-mediated lung allograft rejection.Science translational medicine · 2017Article
- Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Regulation of hematopoietic development by ZBTB transcription factors.International journal of hematology · 2016Review
- What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3⁺ Treg cell function in the intestine.Mucosal immunology · 2015Article
- A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells.Nature immunology · 2014Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
T helper (Th) cells are critical for defenses against infection and recognize peptides bound to class II major histocompatibility complex (MHC II) molecules. Although transcription factors have been identified that direct Th cells into specific effector fates, whether a "master" regulator controls the developmental program common to all Th cells remains unclear. Here, we showed that the two transcription factors Thpok and LRF share this function. Although disruption of both factors did not prevent the generation of MHC II-specific T cells, these cells failed to express Th cell genes or undergo Th cell differentiation in vivo. In contrast, T cells lacking Thpok, which only displayed LRF-dependent functions, contributed to multiple effector responses, both in vitro and in vivo, with the notable exception of Th2 cell responses that control extracellular parasites. These findings identify the Thpok-LRF pair as a core node of Th cell differentiation and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.