Evidence map›Paper›PMID 23040899›Full record

ReviewChild and adolescent psychiatric clinics of North America2012

Interventions for youth at high risk for bipolar disorder and schizophrenia.

Robert K McNamara, Jeffrey R Strawn, Kiki D Chang, Melissa P DelBello

Abstract readReview
In one paragraph

Review in Child and adolescent psychiatric clinics of North America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Assessment of first and second degree relatives of individuals with bipolar disorder shows increased genetic risk scores in both affected relatives and young At-Risk Individuals.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Robert K McNamaraDivision of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Jeffrey R Strawn
Kiki D Chang
Melissa P DelBello
University of Cincinnati Medical Center · USStanford University · US

Funding

U of Cincinnati Bipolar Disorder Imaging & Treatment Research Center (BITREC)P50MH077138 · NIMH · UNIVERSITY OF CINCINNATI · PI STRAKOWSKI, STEPHEN M · 2007 to 2011
$9.6M
Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for ManiaR34MH083924 · NIMH · UNIVERSITY OF CINCINNATI · PI DELBELLO, MELISSA P, MCNAMARA, ROBERT K. · 2009 to 2011
$704k
NIMH NIH HHS P50 MH077138NIMH NIH HHS R34 MH083924
6 · The paper itself

Abstract

Increasing evidence from retrospective and prospective studies is beginning to validate criteria to identify individuals at high risk for developing bipolar disorder or schizophrenia. In parallel, intervention trials are evaluating the efficacy and tolerability of pharmacologic and nonpharmacologic approaches for the treatment of subthreshold and possibly prodromal presentations in these high-risk populations with the ultimate objective of mitigating illness progression. This article reviews current evidence for candidate interventions for high-risk individuals to guide future research in this rapidly emerging field. A clinical vignette describing antidepressant-induced manic symptoms in an adolescent with a family history of bipolar disorder is provided.

Indexed as

Early Medical InterventionProdromal SymptomsAdolescentAntidepressive AgentsAntipsychotic AgentsBipolar DisorderHumansPsychotic DisordersRisk FactorsSchizophreniaAntidepressive AgentsAntipsychotic Agents

Identifiers

PMID23040899
PMCPMC3466439
OpenAlexW2153370042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.