ArticleJournal of biomechanics2012
Cell viability in intervertebral disc under various nutritional and dynamic loading conditions: 3d finite element analysis.
Article in Journal of biomechanics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- The Impact of Modern Lifestyles on Spinal Health in the Pediatric Population: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Finite element models of intervertebral disc: recent advances and prospects.Annals of medicine · 2025Review
- Characterizing the Baseline Regional Biphasic Mechanical Properties of Cervical Intervertebral Discs.Annals of biomedical engineering · 2025Article
- Numerical study on the effect of microgravity on biomechanics in human lumbar intervertebral discs.NPJ microgravity · 2025Article
- The dual effects of iron deficiency on intervertebral disc development and on acute injury-induced disc degeneration.Scientific reports · 2025Article
- Characterizing baseline fixed charge density in human cervical intervertebral discs.Journal of biomechanics · 2025Article
- Influence of disc height and strain-dependent solute diffusivity on metabolic transport in patient-personalized intervertebral disc models.Frontiers in bioengineering and biotechnology · 2025Article
- Impact of Tissue Handling and Size Modification on Septal Chondrocyte Viability.The Laryngoscope · 2024Article
- In silico modeling the potential clinical effect of growth factor treatment on the metabolism of human nucleus pulposus cells.JOR spine · 2024Article
- ISSLS prize in clinical/bioengineering science 2024: How standing and supine positions influence nutrient transport in human lumbar discs?-A serial post-contrast MRI study evaluating interplay between convection and diffusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Analysis of Extracellular ATP Distribution in the Intervertebral Disc.Annals of biomedical engineering · 2024Article
- Future of low back pain: unravelling IVD components and MSCs' potential.Cell regeneration (London, England) · 2024Review
- Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research.JOR spine · 2023Review
- ISSLS PRIZE in basic science 2023: Lactate in lumbar discs-metabolic waste or energy biofuel? Insights from in vivo MRS and T2r analysis following exercise and nimodipine in healthy volunteers.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Review
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- Patient-specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs.JOR spine · 2021Article
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- Computational Modeling Intervertebral Disc Pathophysiology: A Review.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In this study, a new cell density model was developed and incorporated into the formulation of the mechano-electrochemical mixture theory to investigate the effects of deprivation of nutrition supply at boundary source, degeneration, and dynamic loading on the cell viability of intervertebral disc (IVD) using finite element methods. The deprivation of nutrition supply at boundary source was simulated by reduction in nutrition level at CEP and AF boundaries. Cases with 100%, 75%, 60%, 50% and 30% of normal nutrition level at both CEP and AF boundaries were modeled. Unconfined axial sinusoidal dynamic compressions with different combinations of amplitude (u=10%± 2.5%, ± 5%) and frequency (f=1, 10, 20 cycle/day) were applied. Degenerated IVD was modeled with altered material properties. Cell density decreased substantially with reduction of nutrition level at boundaries. Cell death was initiated primarily near the NP-AF interface on the mid-plane. Dynamic loading did not result in a change in the cell density in non-degenerated IVD, since glucose levels did not fall below the minimum value for cell survival; in degenerated IVDs, we found that increasing frequency and amplitude both resulted in higher cell density, because dynamic compression facilitates the diffusion of nutrients and thus increases the nutrition level around IVD cells. The novel computational model can be used to quantitatively predict both when and where cells start to die within the IVD under various kinds of nutritional and mechanical conditions.
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Registered trials
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