Evidence map›Paper›PMID 23040794›Full record

ArticlePsychiatry research2013

Prevalence and clinical correlates of explosive outbursts in Tourette syndrome.

Kevin Chen, Cathy L Budman, Luis Diego Herrera, Joanna E Witkin, Nicholas T Weiss, Thomas L Lowe, Nelson B Freimer, Victor I Reus, Carol A Mathews

Abstract read
In one paragraph

Article in Psychiatry research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Aggression Toward Others Misdiagnosed as Primary Tics.Movement disorders clinical practice · 2021
    Article
  11. Language evolution: examining the link between cross-modality and aggression through the lens of disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Article
  12. Serious Transport Accidents in Tourette Syndrome or Chronic Tic Disorder.Movement disorders : official journal of the Movement Disorder Society · 2021
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. The rise of moral emotions in neuropsychiatry.Dialogues in clinical neuroscience · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kevin ChenDepartment of Psychiatry, University of California San Francisco, CA 94143-0984, USA.
Cathy L Budman
Luis Diego Herrera
Joanna E Witkin
Nicholas T Weiss
Thomas L Lowe
Nelson B Freimer
Victor I Reus
Carol A Mathews

Funding

WHITE MATTER STRUCTURAL DEFICITS IN HIGH FUNCTIONING CHILDREN WITH AUTISM SPEM01RR018535 · NCRR · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI SCHWARTZ, GUY · 2003 to 2010
$19.5M
POPULATION GENETIC MAPPING OF TOURETTE SYNDROMER01NS037484 · NINDS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI FREIMER, NELSON B. · 1998 to 2009
$4.0M
MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWK23RR015533 · NCRR · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MATHEWS, CAROL A. · 2000 to 2004
$608k
NCRR NIH HHS K23 RR015533NCRR NIH HHS M01 RR018535NINDS NIH HHS R01 NS037484PHS HHS R01444653
6 · The paper itself

Abstract

The aim of this study was to examine the prevalence and clinical correlates of explosive outbursts in two large samples of individuals with Tourette syndrome (TS), including one collected primarily from non-clinical sources. Participants included 218 TS-affected individuals who were part of a genetic study (N=104 from Costa Rica (CR) and N=114 from the US). The relationships between explosive outbursts and comorbid attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), tic severity, and prenatal and perinatal complications were examined using regression analyses. Twenty percent of participants had explosive outbursts, with no significant differences in prevalence between the CR (non-clinical) and the US (primarily clinical) samples. In the overall sample, ADHD, greater tic severity, and lower age of tic onset were strongly associated with explosive outbursts. ADHD, prenatal exposure to tobacco, and male gender were significantly associated with explosive outbursts in the US sample. Lower age of onset and greater severity of tics were significantly associated with explosive outbursts in the CR sample. This study confirms previous studies that suggest that clinically significant explosive outbursts are common in TS and associated with ADHD and tic severity. An additional potential risk factor, prenatal exposure to tobacco, was also identified.

Indexed as

RageAdolescentAdultAgedChildChild, PreschoolCosta RicaFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsTourette SyndromeUnited StatesYoung Adult

Identifiers

PMID23040794
PMCPMC3543492

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.