ArticleClinical and experimental immunology2012
Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes.
Article in Clinical and experimental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Prevalence of Inflammatory Pathways Over Immuno-Tolerance in Peripheral Blood Mononuclear Cells of Recent-Onset Type 1 Diabetes.Frontiers in immunology · 2021Trial
- Type 1 diabetes mellitus (T1DM) does not affect whole blood responses to alginate-based microspheres despite plasma lipid and glucose differences.Materials today. Bio · 2025Article
- Identification of crucial extracellular genes as potential biomarkers in newly diagnosed Type 1 diabetesPeerJ · 2025Article
- Gene Expression Analysis of the Pre-Diabetic Pancreas to Identify Pathogenic Mechanisms and Biomarkers of Type 1 Diabetes.Frontiers in endocrinology · 2020Article
- Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes.Circulation · 2015Article
- Article
- Estrogen treatment predisposes to severe and persistent vaginal candidiasis in diabetic mice.Journal of diabetes and metabolic disorders · 2014Article
- Unlocking the biology of RAGE in diabetic microvascular complications.Trends in endocrinology and metabolism: TEM · 2014Review
- Autoimmune effector memory T cells: the bad and the good.Immunologic research · 2013Review
- Progress in immune-based therapies for type 1 diabetes.Clinical and experimental immunology · 2013Review
- Immunological biomarkers: catalysts for translational advances in autoimmune diabetes.Clinical and experimental immunology · 2013Article
- From biomarkers to a clue of biology: a computation-aided perspective of immune gene expression profiles in human type 1 diabetes.Frontiers in immunology · 2012Article
- Novel biomarkers in type 1 diabetes.The review of diabetic studies : RDS · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The mRNA levels of a set of immune-related genes were analysed with peripheral blood samples from at-risk, new-onset and long-term type 1 diabetes (T1D) patients, in comparison to those from healthy controls. The selected set includes T lymphocyte genes [CD3G and cytotoxic T lymphocyte-associated antigen 4 (CTLA4)], B lymphocyte genes (CD19 and CD20) and myeloid cell-related genes [CD11b, Toll-like receptor (TLR)-9, arginase (ARG1)]. Also included is a subset of the S100 family members that has been documented recently as regulatory elements of innate immunity. Samples from patients with long-term T1D had a reduced level of mRNA for most of selected innate and adaptive immune genes. No such reduction was detected in samples collected from at-risk or new-onset T1D patients. Analyses of regulatory gene expression ratios revealed a dynamic disproportion of CTLA4 versus CD3G expression in samples from at-risk, new-onset and long-term T1D patients. These changes could serve as immunological biomarkers for the status of the immune system during T1D progression and therapeutic interventions.
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Registered trials
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