ArticleBMC complementary and alternative medicine2012
Evidence-based antioxidant activity of the essential oil from Fructus A. zerumbet on cultured human umbilical vein endothelial cells' injury induced by ox-LDL.
Article in BMC complementary and alternative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Ameliorating vascular endothelial injury for lipolysacharide-induced via mitochondrial targeting function of octaarginine-modified essential oil from FructusChinese herbal medicines · 2025Article
- Alpinia zerumbet leaf extract reverses hypertension and improves adverse remodeling in the left ventricle and aorta in spontaneously hypertensive rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- Phytochemicals ofMolecules (Basel, Switzerland) · 2024Review
- Medicinal Plants in the Treatment of Hypertension: A Review.Advanced pharmaceutical bulletin · 2021Review
- The Role of Essential Oils and Their Main Compounds in the Management of Cardiovascular Disease Risk Factors.Molecules (Basel, Switzerland) · 2021Review
- EOFAZ inhibits endothelial‑to‑mesenchymal transition through downregulation of KLF4.International journal of molecular medicine · 2020Article
- Protective effects of essential oil from FructusChinese medicine · 2020Article
- Optimal Extraction Study of Gastrodin-Type Components fromMolecules (Basel, Switzerland) · 2019Article
- Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases.Oxidative medicine and cellular longevity · 2019Review
- Essential Oil from Fructus Alpiniae Zerumbet Protects Human Umbilical Vein Endothelial Cells In Vitro from Injury Induced by High Glucose Levels by Suppressing Nuclear Transcription Factor-Kappa B Signaling.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Enzymatic antioxidant system of endotheliocytes.Doklady. Biochemistry and biophysics · 2016Article
- Buyang Huanwu Decoction attenuates H2O2-induced apoptosis by inhibiting reactive oxygen species-mediated mitochondrial dysfunction pathway in human umbilical vein endothelial cells.BMC complementary and alternative medicine · 2016Article
- Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II.Frontiers in pharmacology · 2016Review
- Essential Oils from Fructus A. zerumbet Protect Human Aortic Endothelial Cells from Apoptosis Induced by Ox-LDL In Vitro.Evidence-based complementary and alternative medicine : eCAM · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe essential oil from Fructus Alpiniae zerumbet (FAZ) is its principal bioactive ingredient, and is widely used in Miao folk herbs in Guizhou province for the treatment of gastrointestinal and cardiovascular diseases. Several studies have confirmed that FAZ ameliorates hyperlipidemia and atherosclerosis. Because endothelial dysfunction often accompanies cardiovascular diseases, especially hyperlipidemia and atherosclerosis, the present study concentrated on evaluating the endothelial protective effects of the essential oil from FAZ (EOFAZ) on oxidized low-density lipoprotein (ox-LDL)-induced injury of cultured human umbilical vein endothelial cells (HUVECs) and on the regulation of oxidative stress.
methodsCell viability was analyzed with the MTT assay and trypan blue exclusion staining (TBES). Cell injury was assessed by lactate dehydrogenase (LDH) release. Biochemical enzymatic methods were used to evaluate the oxidative stress, including the lipid peroxidation product, malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px).
resultsThe redox status of HUVECs was significantly exacerbated after exposure to ox-LDL. EOFAZ protected HUVECs against ox-LDL injury as assessed by the MTT assay, TBES and LDH release. Furthermore, EOFAZ ameliorated the oxidative stress by elevating the activities of SOD, CAT and GSH-Px, and increasing the GSH levels, in addition to attenuating the MDA contents.
conclusionsThe present data provide the first experimental evidence that EOFAZ protects endothelial cells against ox-LDL-induced injury, and indicate that this protection involves ameliorating the redox status.
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