ArticleJournal of cell science2012
Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string.
Article in Journal of cell science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed.
- Three-dimensional mechanical cooperativity optimises epithelial wound healing.The EMBO journal · 2026Article
- Article
- A flexible repertoire of wound closure strategies precedes whole-body regeneration.Nature communications · 2026Article
- The basement membrane determines the choice of wound healing mechanism across wound scales in the basal eukaryoteMolecular biology of the cell · 2026Article
- The LDL pathway regulates actomyosin ring dynamics necessary for optimal cell wound repair.microPublication biology · 2026Article
- Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence during collective cell migration.Nature communications · 2025Article
- Reactive oxygen species counteract zebrafish wound contraction and promote wound healing.Biophysical journal · 2025Article
- ER shaping closes the gap in wound healing.Nature cell biology · 2025Article
- Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode.Nature cell biology · 2025Article
- Actin mesh in Re-epithelialization during skin regeneration in adult newt (Regenerative therapy · 2025Article
- Initiation of epithelial wound closure by an active instability at the purse string.Biophysical journal · 2025Article
- The Enigmas of Tissue Closure: Inspiration fromCurrent issues in molecular biology · 2024Review
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics.Cell reports · 2024Article
- A defined diet for pre-adult Drosophila melanogaster.Scientific reports · 2024Article
- Plasma membrane repair empowers the necrotic survivors as innate immune modulators.Seminars in cell & developmental biology · 2024Review
- Medioapical contractile pulses coordinated between cells regulate Drosophila eye morphogenesis.The Journal of cell biology · 2024Article
- FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor.Development (Cambridge, England) · 2023Article
- Epithelial wound healing in Clytia hemisphaerica provides insights into extracellular ATP signaling mechanisms and P2XR evolution.Scientific reports · 2023Article
- Regeneration in calcareous sponge relies on 'purse-string' mechanism and the rearrangements of actin cytoskeleton.Cell and tissue research · 2023Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The repair of injured tissue must occur rapidly to prevent microbial invasion and maintain tissue integrity. Epithelial tissues in particular, which serve as a barrier against the external environment, must repair efficiently in order to restore their primary function. Here we analyze the effect of different parameters on the epithelial wound repair process in the late stage Drosophila embryo using in vivo wound assays, expression of cytoskeleton and membrane markers, and mutant analysis. We define four distinct phases in the repair process, expansion, coalescence, contraction and closure, and describe the molecular dynamics of each phase. Specifically, we find that myosin, E-cadherin, Echinoid, the plasma membrane, microtubules and the Cdc42 small GTPase respond dynamically during wound repair. We demonstrate that perturbations of each of these components result in specific impairments to the wound healing process. Our results show that embryonic epithelial wound repair is mediated by two simultaneously acting mechanisms: crawling driven by cellular protrusions and actomyosin ring contraction along the leading edge of the wound.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.